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  Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation

Orioli, D., Henkemeyer, M., Lempe, G., Klein, R., & Pawson, T. (1996). Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. The EMBO Journal, 15(22), 6035-6049. doi:10.1002/j.1460-2075.1996.tb00992.x.

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Orioli, D., Author
Henkemeyer, M., Author
Lempe, G., Author
Klein, Rüdiger1, Author           
Pawson, T., Author
Affiliations:
1European Molecular Biology Laboratory, Heidelberg, ou_persistent22              

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Free keywords: axon fasciculation axon guidance Eph-related receptors palate formation tyrosine kinase protein-tyrosine kinase embryonic stem-cells interpeduncular nucleus corpus-callosum nervous-system eph family ligand gene cloning growth Biochemistry & Molecular Biology Cell Biology
 Abstract: Sek4 and Nuk are members of the Eph-related family of receptor protein-tyrosine kinases. These receptors interact with a set of cell surface ligands that have recently been implicated in axon guidance and fasciculation. We now demonstrate that the formation of the corpus callosum and anterior commissure, two major commissural axon tracts that connect the two cerebral hemispheres, is critically dependent on Sek4 and Nuk. While mice deficient in Nuk exhibit defects in pathfinding of anterior commissure axons, sek4 mutants have defects in corpus callosum formation. The phenotype in both axon tracts is markedly more severe in sek4/nuk(1) double mutants, indicating that the two receptors act in a partially redundant fashion. sek4/nuk(1) double mutants also exhibit specific guidance and fasciculation defects of diencephalic axon tracts. Moreover, while mice singly deficient in either Sek4 or Nuk are viable, most sek4/nuk(1) double mutants die immediately after birth primarily due to a cleft palate. These results demonstrate essential and cooperative functions for Sek4 and Nuk in establishing axon pathways in the developing brain, and during the development of facial structures.

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Language(s): eng - English
 Dates: 1996
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: WOS:A1996VW41800004
DOI: 10.1002/j.1460-2075.1996.tb00992.x
ISSN: 0261-4189
 Degree: -

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Title: The EMBO Journal
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Nature Publishing Group
Pages: - Volume / Issue: 15 (22) Sequence Number: - Start / End Page: 6035 - 6049 Identifier: ISSN: 0261-4189
CoNE: https://pure.mpg.de/cone/journals/resource/954925497061_1