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  Survival of inner ear sensory neurons in trk mutant mice

Schimmang, T., AlvarezBolado, G., Minichiello, L., Vazquez, E., Giraldez, F., Klein, R., et al. (1997). Survival of inner ear sensory neurons in trk mutant mice. Mechanisms of Development, 64(1-2), 77-85. doi:10.1016/s0925-4773(97)00047-6.

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Schimmang, T., Autor
AlvarezBolado, G., Autor
Minichiello, L.1, Autor           
Vazquez, E., Autor
Giraldez, F., Autor
Klein, Rüdiger1, Autor           
Represa, J., Autor
Affiliations:
1European Molecular Biology Laboratory, Heidelberg, ou_persistent22              

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Schlagwörter: neurotrophin receptor mouse mutant inner ear sensory neurons central targets nerve growth-factor messenger-rna expression affinity ngf receptor neurotrophic factor ganglion neurons sympathetic neuroblasts vestibular ganglion truncated receptors peripheral targets tyrosine kinase Developmental Biology
 Zusammenfassung: Analysis of trkB(-/-); trkC(-/-) double mutant mice revealed that peripheral and central inner ear sensory neurons are affected in these mice. However, a substantial amount of cochlear and vestibular neurons survive, possibly due to maintenance or upregulation of TrkA expression. To clarify the function of the TrkA receptor during development of the cochlear and vestibular ganglion we analysed trkA(-/-) mice and the expression of this receptor in inner ear sensory neurons of trkB(-/-); trkC(-/-) animals. TrkA homozygous mutant mice showed normal numbers of neurons and no TrkA expression was detected in neurons of trkB(-/-); trkC(-/-) double mutant mice. We conclude that TrkA is not essential for inner ear development and that in the absence of any of the known catalytic Trk receptors peripheral inner ear sensory neurons are prone to undergo cell death or must use a different signaling mechanism to survive. (C) 1997 Elsevier Science Ireland Ltd.

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Sprache(n): eng - English
 Datum: 1997
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: Anderer: WOS:A1997XJ08100007
DOI: 10.1016/s0925-4773(97)00047-6
ISSN: 0925-4773
 Art des Abschluß: -

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Titel: Mechanisms of Development
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Shannon : Elsevier
Seiten: - Band / Heft: 64 (1-2) Artikelnummer: - Start- / Endseite: 77 - 85 Identifikator: ISSN: 0925-4773
CoNE: https://pure.mpg.de/cone/journals/resource/954927703126