ausblenden:
Schlagwörter:
neurotrophin receptor
mouse mutant
inner ear
sensory neurons
central
targets
nerve growth-factor
messenger-rna expression
affinity ngf receptor
neurotrophic factor
ganglion neurons
sympathetic neuroblasts
vestibular ganglion
truncated receptors
peripheral targets
tyrosine
kinase
Developmental Biology
Zusammenfassung:
Analysis of trkB(-/-); trkC(-/-) double mutant mice revealed that peripheral and central inner ear sensory neurons are affected in these mice. However, a substantial amount of cochlear and vestibular neurons survive, possibly due to maintenance or upregulation of TrkA expression. To clarify the function of the TrkA receptor during development of the cochlear and vestibular ganglion we analysed trkA(-/-) mice and the expression of this receptor in inner ear sensory neurons of trkB(-/-); trkC(-/-) animals. TrkA homozygous mutant mice showed normal numbers of neurons and no TrkA expression was detected in neurons of trkB(-/-); trkC(-/-) double mutant mice. We conclude that TrkA is not essential for inner ear development and that in the absence of any of the known catalytic Trk receptors peripheral inner ear sensory neurons are prone to undergo cell death or must use a different signaling mechanism to survive. (C) 1997 Elsevier Science Ireland Ltd.
