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  Functional connectivity alterations between default mode network and occipital cortex in patients with obsessive-compulsive disorder (OCD)

Geffen, T., Smallwood, J., Finke, C., Olbrich, S., Sjoerds, Z., & Schlagenhauf, F. (2021). Functional connectivity alterations between default mode network and occipital cortex in patients with obsessive-compulsive disorder (OCD). NeuroImage: Clinical, 33: 102915. doi:10.1016/j.nicl.2021.102915.

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 Creators:
Geffen, Tal1, Author
Smallwood, Jonathan2, Author
Finke, Carsten3, 4, Author
Olbrich, Sebastian5, Author
Sjoerds, Zsuzsika6, 7, Author
Schlagenhauf, Florian1, 8, 9, Author              
Affiliations:
1Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Psychology, Queen’s University, Kingston, ON, Canada, ou_persistent22              
3Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
4Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
5Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Zurich, Switzerland, ou_persistent22              
6Cognitive Psychology Unit, Institute of Psychology, Leiden University, the Netherlands, ou_persistent22              
7Leiden Institute for Brain and Cognition, Leiden University, the Netherlands, ou_persistent22              
8Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
9Bernstein Center for Computational Neuroscience, Berlin, Germany, ou_persistent22              

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Free keywords: OCD; Resting-state fMRI; Seed analysis; Functional connectivity; Neuropsychiatry
 Abstract: Altered brain network connectivity is a potential biomarker for obsessive–compulsive disorder (OCD). A meta-analysis of resting-state MRI studies by Gürsel et al. (2018) described altered functional connectivity in OCD patients within and between the default mode network (DMN), the salience network (SN), and the frontoparietal network (FPN), as well as evidence for aberrant fronto-striatal circuitry. Here, we tested the replicability of these meta-analytic rsfMRI findings by measuring functional connectivity during resting-state fMRI in a new sample of OCD patients (n = 24) and matched controls (n = 33). We performed seed-to-voxel analyses using 30 seed regions from the prior meta-analysis. OCD patients showed reduced functional connectivity between the SN and the DMN compared to controls, replicating previous findings. We did not observe significant group differences of functional connectivity within the DMN, SN, nor FPN. Additionally, we observed reduced connectivity between the visual network to both the DMN and SN in OCD patients, in particular reduced functional connectivity between lateral parietal seeds and the left inferior lateral occipital pole. Furthermore, the right lateral parietal seed (associated with the DMN) was more strongly correlated with a cluster in the right lateral occipital cortex and precuneus (a region partly overlapping with the Dorsal Attentional Network (DAN)) in patients. Importantly, this latter finding was positively correlated to OCD symptom severity. Overall, our study partly replicated prior meta-analytic findings, highlighting hypoconnectivity between SN and DMN as a potential biomarker for OCD. Furthermore, we identified changes between the SN and the DMN with the visual network. This suggests that abnormal connectivity between cortex regions associated with abstract functions (transmodal regions such as the DMN), and cortex regions associated with constrained neural processing (unimodal regions such as the visual cortex), may be important in OCD.

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Language(s): eng - English
 Dates: 2021-11-062021-08-272021-12-122021-12-16
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.nicl.2021.102915
Other: epub 2021
PMID: 34933233
PMC: PMC8688720
 Degree: -

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Project name : -
Grant ID : Rubicon 2014/05563/ALW
Funding program : -
Funding organization : Netherlands Organization for Scientific Research
Project name : -
Grant ID : SCHL 1969/5-1
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : /57381412
Funding program : -
Funding organization : Deutscher Akademischer Austauschdienst

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Title: NeuroImage: Clinical
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Elsevier
Pages: - Volume / Issue: 33 Sequence Number: 102915 Start / End Page: - Identifier: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582