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  Free triiodothyronine (T3) is negatively associated with fasting ghrelin serum levels in a population sample of euthyroid subjects

Wittekind, D. A., Kratzsch, J., Mergl, R., Baber, R., Witte, A. V., Villringer, A., et al. (2021). Free triiodothyronine (T3) is negatively associated with fasting ghrelin serum levels in a population sample of euthyroid subjects. Journal of Endocrinological Investigation, 44, 2655-2664. doi:10.1007/s40618-021-01578-5.

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 Creators:
Wittekind, D. A.1, Author
Kratzsch, J.2, Author
Mergl, R.3, Author
Baber, R.2, 4, Author
Witte, A. Veronica5, Author              
Villringer, Arno5, Author              
Kluge, M.1, Author
Affiliations:
1Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Germany, ou_persistent22              
2Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University of Leipzig, Germany, ou_persistent22              
3Institute of Psychology, Bundeswehr University Munich, Germany, ou_persistent22              
4Leipzig Research Center for Civilization Diseases (LIFE), University of Leipzig, Germany, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Ghrelin; Homeostasis; Iodothyronine deiodinase; Metabolism; Thyroid
 Abstract: Purpose: Ghrelin is an orexigenic peptide hormone secreted in times of stress and hunger. It is deeply involved in the regulation of metabolism and energy homeostasis, promoting energy intake and inhibiting energy expenditure on a metabolic level. In this regard, it has in many ways antagonistic effect on the thyroid hormones, which increase metabolism and thus energy expenditure. While there is reasonable evidence of a negative association between ghrelin and hormones of the hypothalamic-pituitary-thyroid (HPT-) axis from studies in patients with thyroid dysfunction and small intervention studies, large-scale studies in healthy subjects are lacking. Therefore, we studied the relationship between total ghrelin serum levels and serum levels of the thyroid hormones in a large sample of euthyroid subjects. Methods: Total ghrelin, thyroid-stimulating hormone (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were determined after an overnight fast in 1666 subjects participating in a population-based cross-sectional study ('LIFE') including 10,000 adults. 1012 subjects were included in this analysis. Multiple linear regression analyses were performed. Results: FT3 was negatively associated with serum ghrelin; total sample: β = - 0.0001, p < 0.001; men: β = - 0.0002, p = 0.013; women: β = - 0.0001, p = 0.010, adjusted for age, BMI, alcohol consumption, serum levels of TSH and fT4 and smoking status. No associations were found between ghrelin serum levels and serum levels of fT4 or TSH. Conclusion: This is to date the largest study investigating the relationship between total serum ghrelin and thyroid hormones. The results point to a complex interaction and should initiate further research.

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Language(s): eng - English
 Dates: 2021-01-272021-04-102021-04-212021-12
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1007/s40618-021-01578-5
Other: epub 2021
PMID: 33881751
PMC: PMC8572188
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Title: Journal of Endocrinological Investigation
  Other : J. Endocrinol. Invest.
Source Genre: Journal
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Pages: - Volume / Issue: 44 Sequence Number: - Start / End Page: 2655 - 2664 Identifier: ISSN: 0391-4097
CoNE: https://pure.mpg.de/cone/journals/resource/954925529888