English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

Gupta, K., Toelzer, C., Williamson, M. K., Shoemark, D. K., Oliveira, A. S. F., Matthews, D. A., et al. (2022). Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2. Nature Communications, 16: 222, pp. 1-12. doi:10.1038/s41467-021-27881-6.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
NatCommun_13_2022_222.pdf (Any fulltext), 2MB
 
File Permalink:
-
Name:
NatCommun_13_2022_222.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatCommun_13_2022_222_Suppl1.pdf (Supplementary material), 4MB
 
File Permalink:
-
Name:
NatCommun_13_2022_222_Suppl1.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatCommun_13_2022_222_Suppl2.pdf (Supplementary material), 2MB
 
File Permalink:
-
Name:
NatCommun_13_2022_222_Suppl2.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatCommun_13_2022_222_Suppl3.pdf (Supplementary material), 379KB
 
File Permalink:
-
Name:
NatCommun_13_2022_222_Suppl3.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatCommun_13_2022_222_Suppl4.avi (Supplementary material), 42MB
 
File Permalink:
-
Name:
NatCommun_13_2022_222_Suppl4.avi
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
video/x-msvideo
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-
:
NatCommun_13_2022_222_Suppl5.pdf (Supplementary material), 3MB
 
File Permalink:
-
Name:
NatCommun_13_2022_222_Suppl5.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Gupta, Kapil, Author
Toelzer, Christine, Author
Williamson, Maia Kavanagh, Author
Shoemark, Deborah K., Author
Oliveira, A. Sofia F., Author
Matthews, David A., Author
Almuqrin, Abdulaziz, Author
Staufer, Oskar1, Author              
Yadav, Sathish K. N., Author
Borucu, Ufuk, Author
Garzoni, Frederic, Author
Fitzgerald, Daniel, Author
Spatz, Joachim1, Author              
Mulholland, Adrian J., Author
Davidson, Andrew D., Author
Schaffitzel, Christiane, Author
Berger, Imre, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

Content

show
hide
Free keywords: -
 Abstract: As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also display genetic diversity within single infected hosts with co-existing viral variants evolving differently in distinct cell types. The BriSΔ variant, originally identified as a viral subpopulation from SARS-CoV-2 isolate hCoV-19/England/02/2020, comprises in the spike an eight amino-acid deletion encompassing a furin recognition motif and S1/S2 cleavage site. We elucidate the structure, function and molecular dynamics of this spike providing mechanistic insight into how the deletion correlates to viral cell tropism, ACE2 receptor binding and infectivity of this SARS-CoV-2 variant. Our results reveal long-range allosteric communication between functional domains that differ in the wild-type and the deletion variant and support a view of SARS-CoV-2 probing multiple evolutionary trajectories in distinct cell types within the same infected host.

Details

show
hide
Language(s): eng - English
 Dates: 2021-06-282021-12-162022-01-11
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-27881-6
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 16 Sequence Number: 222 Start / End Page: 1 - 12 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723