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  Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

Gupta, K., Toelzer, C., Williamson, M. K., Shoemark, D. K., Oliveira, A. S. F., Matthews, D. A., et al. (2022). Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2. Nature Communications, 16: 222, pp. 1-12. doi:10.1038/s41467-021-27881-6.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-CA25-A Version Permalink: https://hdl.handle.net/21.11116/0000-0009-CA26-9
Genre: Journal Article

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 Creators:
Gupta, Kapil, Author
Toelzer, Christine, Author
Williamson, Maia Kavanagh, Author
Shoemark, Deborah K., Author
Oliveira, A. Sofia F., Author
Matthews, David A., Author
Almuqrin, Abdulaziz, Author
Staufer, Oskar1, Author           
Yadav, Sathish K. N., Author
Borucu, Ufuk, Author
Garzoni, Frederic, Author
Fitzgerald, Daniel, Author
Spatz, Joachim1, Author           
Mulholland, Adrian J., Author
Davidson, Andrew D., Author
Schaffitzel, Christiane, Author
Berger, Imre, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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 Abstract: As the global burden of SARS-CoV-2 infections escalates, so does the evolution of viral variants with increased transmissibility and pathology. In addition to this entrenched diversity, RNA viruses can also display genetic diversity within single infected hosts with co-existing viral variants evolving differently in distinct cell types. The BriSΔ variant, originally identified as a viral subpopulation from SARS-CoV-2 isolate hCoV-19/England/02/2020, comprises in the spike an eight amino-acid deletion encompassing a furin recognition motif and S1/S2 cleavage site. We elucidate the structure, function and molecular dynamics of this spike providing mechanistic insight into how the deletion correlates to viral cell tropism, ACE2 receptor binding and infectivity of this SARS-CoV-2 variant. Our results reveal long-range allosteric communication between functional domains that differ in the wild-type and the deletion variant and support a view of SARS-CoV-2 probing multiple evolutionary trajectories in distinct cell types within the same infected host.

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Language(s): eng - English
 Dates: 2021-06-282021-12-162022-01-11
 Publication Status: Published online
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-021-27881-6
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 16 Sequence Number: 222 Start / End Page: 1 - 12 Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723