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  The human mediodorsal thalamus: Organization, connectivity, and function

Li, K., Fan, L., Cui, Y., Wei, X., He, Y., Yang, J., et al. (2022). The human mediodorsal thalamus: Organization, connectivity, and function. NeuroImage, 249: 118876. doi:10.1016/j.neuroimage.2022.118876.

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 Creators:
Li, Kaixin1, 2, 3, Author
Fan, Lingzhong2, 3, 4, 5, Author
Cui, Yue2, 3, 5, Author
Wei, Xuehu6, Author              
He, Yini7, Author
Yang, Jiyue2, 3, 5, Author
Lu, Yuheng2, 3, 5, Author
Li, Wen2, 3, 5, Author
Shi, Weiyang2, 3, 5, Author
Cao, Long2, 3, 8, Author
Cheng, Luqi2, 3, 9, Author
Li, Ang10, Author
You, Bo1, Author
Jiang, Tianzi2, 3, 4, 5, 8, 11, Author
Affiliations:
1School of Mechanical and Power Engineering, Harbin University of Science and Technology, China, ou_persistent22              
2Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Peking, China, ou_persistent22              
3National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Peking, China, ou_persistent22              
4CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Peking, China, ou_persistent22              
5School of Artificial Intelligence, Chinese Academy of Sciences, Peking, China, ou_persistent22              
6Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
7State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China, ou_persistent22              
8Key Laboratory for Neuroinformation, School of Life Science & Technology, University of Electronic Science and Technology of China, Chengdu, China, ou_persistent22              
9School of Life and Environmental Sciences, Guilin University of Electronic Technology, China, ou_persistent22              
10State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Peking, China, ou_persistent22              
11Queensland Brain Institute, University of Queensland, Brisbane, Australia, ou_persistent22              

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Free keywords: Mediodorsal thalamic nucleus; Parcellation; Anatomical organization; Functional connectivity; Cognitive functions
 Abstract: The human mediodorsal thalamic nucleus (MD) is crucial for higher cognitive functions, while the fine anatomical organization of the MD and the function of each subregion remain elusive. In this study, using high-resolution data provided by the Human Connectome Project, an anatomical connectivity-based method was adopted to unveil the topographic organization of the MD. Four fine-grained subregions were identified in each hemisphere, including the medial (MDm), central (MDc), dorsal (MDd), and lateral (MDl), which recapitulated previous cytoarchitectonic boundaries from histological studies. The subsequent connectivity analysis of the subregions also demonstrated distinct anatomical and functional connectivity patterns, especially with the prefrontal cortex. To further evaluate the function of MD subregions, partial least squares analysis was performed to examine the relationship between different prefrontal-subregion connectivity and behavioral measures in 1012 subjects. The results showed subregion-specific involvement in a range of cognitive functions. Specifically, the MDm predominantly subserved emotional-cognition domains, while the MDl was involved in multiple cognitive functions especially cognitive flexibility and inhibition. The MDc and MDd were correlated with fluid intelligence, processing speed, and emotional cognition. In conclusion, our work provides new insights into the anatomical and functional organization of the MD and highlights the various roles of the prefrontal-thalamic circuitry in human cognition.

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Language(s): eng - English
 Dates: 2021-12-062021-07-212022-01-042022-01-052022-04-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.118876
Other: epub 2022
PMID: 34998970
 Degree: -

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Project name : -
Grant ID : 91432302, 31620103905, 82072099 and 31771076
Funding program : -
Funding organization : National Natural Science Foundation of China
Project name : -
Grant ID : QYZDJ-SSW-SMC019
Funding program : -
Funding organization : Science Frontier Program of the Chinese Academy of Sciences
Project name : -
Grant ID : Z161100000216139, Z171100000117002
Funding program : -
Funding organization : Beijing Municipal Science and Technology Commission
Project name : -
Grant ID : 2016ZT06S220
Funding program : -
Funding organization : Guangdong Pearl River Talents Plan

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 249 Sequence Number: 118876 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166