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  Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T

Dorst, J., Borbath, T., Landheer, K., Avdievich, N., & Henning, A. (2022). Simultaneous detection of metabolite concentration changes, water BOLD signal and pH changes during visual stimulation in the human brain at 9.4T. Journal of Cerebral Blood Flow and Metabolism, 42(6), 1104-1119. doi:10.1177/0271678X221075892.

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Dorst, J1, 2, Author              
Borbath, T1, 2, Author              
Landheer, K, Author
Avdievich, N1, 2, Author              
Henning, A1, 2, Author              
Affiliations:
1Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528692              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: This study presents a method to directly link metabolite concentration changes and BOLD response in the human brain during visual stimulation by measuring the water and metabolite signals simultaneously. Therefore, the metabolite-cycling (MC) non-water suppressed semiLASER localization technique was optimized for functional 1H MRS in the human brain at 9.4 T. Data of 13 volunteers were acquired during a 26:40 min visual stimulation block-design paradigm. Activation-induced BOLD signal was observed in the MC water signal as well as in the NAA-CH3 and tCr-CH3 singlets. During stimulation, glutamate concentration increased 2.3 ± 2.0% to a new steady-state, while a continuous increase over the whole stimulation period could be observed in lactate with a mean increase of 35.6 ± 23.1%. These increases of Lac and Glu during brain activation confirm previous findings reported in literature. A positive correlation of the MC water BOLD signal with glutamate and lactate concentration changes was found. In addition, a pH decrease calculated from a change in the ratio of PCr to Cr was observed during brain activation, particularly at the onset of the stimulation.

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 Dates: 2022-012022-06
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1177/0271678X221075892
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Title: Journal of Cerebral Blood Flow and Metabolism
Source Genre: Journal
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Publ. Info: New York : Lippincott Williams & Wilkins
Pages: - Volume / Issue: 42 (6) Sequence Number: - Start / End Page: 1104 - 1119 Identifier: ISSN: 0271-678X
CoNE: https://pure.mpg.de/cone/journals/resource/954925503202