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  Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI

Miletić, S., Bazin, P.-L., Isherwood, S. J., Keuken, M. C., Alkemade, A., & Forstmann, B. U. (2022). Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI. NeuroImage, 249: 118872. doi:10.1016/j.neuroimage.2022.118872.

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Miletic_2022.pdf (Publisher version), 5MB
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 Creators:
Miletić, Steven1, Author
Bazin, Pierre-Louis1, 2, Author              
Isherwood, Scott J.S.1, Author
Keuken, Max C.1, Author
Alkemade, Anneke1, Author
Forstmann, Birte U.1, Author
Affiliations:
1Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, the Netherlands, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Subcortex; Morphometry; Iron; Myelin; Aging
 Abstract: The human subcortex comprises hundreds of unique structures. Subcortical functioning is crucial for behavior, and disrupted function is observed in common neurodegenerative diseases. Despite their importance, human subcortical structures continue to be difficult to study in vivo. Here we provide a detailed account of 17 prominent subcortical structures and ventricles, describing their approximate iron and myelin contents, morphometry, and their age-related changes across the normal adult lifespan. The results provide compelling insights into the heterogeneity and intricate age-related alterations of these structures. They also show that the locations of many structures shift across the lifespan, which is of direct relevance for the use of standard magnetic resonance imaging atlases. The results further our understanding of subcortical morphometry and neuroimaging properties, and of normal aging processes which ultimately can improve our understanding of neurodegeneration.

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Language(s): eng - English
 Dates: 2021-12-202021-07-192022-01-032022-01-072022-04-01
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.118872
Other: epub 2022
PMID: 34999202
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 249 Sequence Number: 118872 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166