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  Mandipropamid as a chemical inducer of proximity for in vivo applications

Ziegler, M. J., Yserentant, K., Dunsing, V., Middel, V., Gralak, A. J., Pakari, K., et al. (2022). Mandipropamid as a chemical inducer of proximity for in vivo applications. Nature Chemical Biology, 18, 64-69. doi:10.1038/s41589-021-00922-3.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-DBAC-F Version Permalink: https://hdl.handle.net/21.11116/0000-0009-DBAD-E
Genre: Journal Article

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 Creators:
Ziegler, Michael J.1, Author           
Yserentant, Klaus, Author
Dunsing, Valentin, Author
Middel, Volker, Author
Gralak, Antoni J, Author
Pakari, Kaisa., Author
Bargstedt, Jörn, Author
Kern, Christoph, Author
Petrich, Annett, Author
Chiantia, Salvatore, Author
Strähle, Uwe, Author
Herten, Dirk-Peter, Author
Wombacher, Richard1, Author           
Affiliations:
1Chemical Biology, Max Planck Institute for Medical Research, Max Planck Society, ou_2364732              

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 Abstract: Direct control of protein interactions by chemically induced protein proximity holds great potential for both cell and synthetic biology as well as therapeutic applications. Low toxicity, orthogonality and excellent cell permeability are important criteria for chemical inducers of proximity (CIPs), in particular for in vivo applications. Here, we present the use of the agrochemical mandipropamid (Mandi) as a highly efficient CIP in cell culture systems and living organisms. Mandi specifically induces complex formation between a sixfold mutant of the plant hormone receptor pyrabactin resistance 1 (PYR1) and abscisic acid insensitive (ABI). It is orthogonal to other plant hormone-based CIPs and rapamycin-based CIP systems. We demonstrate the applicability of the Mandi system for rapid and efficient protein translocation in mammalian cells and zebrafish embryos, protein network shuttling and manipulation of endogenous proteins.

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Language(s): ang - Old English (ca. 450-1100)
 Dates: 2020-09-092021-10-132021-12-212022-01-01
 Publication Status: Issued
 Pages: 21
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41589-021-00922-3
URI: https://pubmed.ncbi.nlm.nih.gov/34934192/
 Degree: -

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Title: Nature Chemical Biology
  Other : Nat. Chem. Biol.
Source Genre: Journal
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Publ. Info: New York, NY : Nature Pub. Group
Pages: - Volume / Issue: 18 Sequence Number: - Start / End Page: 64 - 69 Identifier: ISSN: 1552-4450
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000021290_1