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  Variability in brain structure and function reflects lack of peer support

Schurz, M., Uddin, L. Q., Kanske, P., Lamm, C., Sallet, J., Bernhardt, B. C., et al. (2021). Variability in brain structure and function reflects lack of peer support. Cerebral Cortex, 31(10), 4612-4627. doi:10.1093/cercor/bhab109.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-DBCD-A Version Permalink: https://hdl.handle.net/21.11116/0000-000D-599E-E
Genre: Journal Article

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 Creators:
Schurz, Matthias1, 2, 3, Author
Uddin, Lucina Q.4, 5, Author
Kanske, Philipp6, 7, Author           
Lamm, Claus8, Author
Sallet, Jérôme2, 9, Author
Bernhardt, Boris C.10, Author
Mars, Rogier B.1, 11, Author
Bzdok, Danilo10, 12, 13, Author
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
2Wellcome Centre For Integrative Neuroimaging, University of Oxford, United Kingdom, ou_persistent22              
3Institute of Psychology, University of Innsbruck, Austria, ou_persistent22              
4Department of Psychology, University of Miami, Coral Gables, FL, USA, ou_persistent22              
5Neuroscience Program, University of Miami Miller School of Medicine, FL, USA, ou_persistent22              
6Chair for Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, TU Dresden, Germany, ou_persistent22              
7Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
8Social, Cognitive and Affective Neuroscience Unit, Department of Basic Psychological Research and Research Methods, Faculty of Psychology, University Vienna, Austria, ou_persistent22              
9Stem Cell and Brain Research Institute, University of Lyon, France, ou_persistent22              
10McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, QC, Canada, ou_persistent22              
11Nuffield Department Clinical Neurosciences, FMRIB Centre, University of Oxford, United Kingdom, ou_persistent22              
12Department of Biomedical Engineering, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              
13Mila – Quebec Artificial Intelligence Institute, Montréal, QC, Canada, ou_persistent22              

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Free keywords: Bayesian hierarchical modeling; Machine learning; Population neuroscience; Salience network; Social brain
 Abstract: Humans are a highly social species. Complex interactions for mutual support range from helping neighbors to building social welfare institutions. During times of distress or crisis, sharing life experiences within one's social circle is critical for well-being. By translating pattern-learning algorithms to the UK Biobank imaging-genetics cohort (n = ~40 000 participants), we have delineated manifestations of regular social support in multimodal whole-brain measurements. In structural brain variation, we identified characteristic volumetric signatures in the salience and limbic networks for high- versus low-social support individuals. In patterns derived from functional coupling, we also located interindividual differences in social support in action-perception circuits related to binding sensory cues and initiating behavioral responses. In line with our demographic profiling analysis, the uncovered neural substrates have potential implications for loneliness, substance misuse, and resilience to stress.

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Language(s): eng - English
 Dates: 2021-03-022020-12-312021-03-242021-05-132021-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhab109
PMID: 33982758
PMC: PMC8408465
 Degree: -

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Project name : -
Grant ID : R01AG068563A
Funding program : -
Funding organization : National Institutes of Health (NIH)
Project name : -
Grant ID : SCHN 1481/2-1; KA 4412/2-1; KA 4412/4-1; KA 4412/5-1; CRC940/C07
Funding program : -
Funding organization : German Research Foundation (DFG)
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Grant ID : 203139/Z/16/Z
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : R01MH107549
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Funding organization : National Institute of Mental Health (NIMH)
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Grant ID : IDEX/IMP/2020/14
Funding program : -
Funding organization : IDEXLYON IMPULSION
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Grant ID : Discovery-1304413
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Funding organization : National Science and Engineering Research Council of Canada (NSERC)
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Grant ID : FDN-154298
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Funding organization : Canadian Institutes of Health Research (CIHR)
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Grant ID : NI17-039
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Funding organization : SickKids Foundation
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Grant ID : BB/N019814/1
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Funding organization : Biotechnology and Biological Sciences Research Council (BBSRC)
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Grant ID : 452-13-015
Funding program : -
Funding organization : Netherlands Organization for Scientific Research (NWO)
Project name : This is only an excerpt. You can find the complete funding information on the article page.
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Title: Cerebral Cortex
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 31 (10) Sequence Number: - Start / End Page: 4612 - 4627 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440