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  The role of the orbitofrontal cortex in creating cognitive maps

Machado Costa, K., Scholz, R., Lloyd, K., Moreno-Castilla, P., Gardner, M., Dayan, P., et al. (submitted). The role of the orbitofrontal cortex in creating cognitive maps.

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 Creators:
Machado Costa, K, Author
Scholz, R1, 2, Author              
Lloyd, K1, 2, Author              
Moreno-Castilla, P, Author
Gardner, MPH, Author
Dayan, P1, 2, Author              
Schoenbaum, G, Author
Affiliations:
1Department of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_3017468              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: We use internal models of the external world to guide behavior, but little is known about how these cognitive maps are created. The orbitofrontal cortex (OFC) is typically thought to access these maps to support model-based decision-making, but it has recently been proposed that its critical contribution may be instead to integrate information into existing and new models. We tested between these alternatives using an outcome-specific devaluation task and a high-potency chemogenetic approach. We found that selectively inactivating OFC principal neurons when rats learned distinct cue-outcome associations, but prior to outcome devaluation, disrupted subsequent model-based inference, confirming that the OFC is critical for creating new cognitive maps. However, OFC inactivation surprisingly led to generalized devaluation. Using a novel reinforcement learning framework, we demonstrate that this effect is best explained not by a switch to a model-free system, as would be traditionally assumed, but rather by a circumscribed deficit in defining credit assignment precision during model construction. We conclude that the critical contribution of the OFC to learning is regulating the specificity of associations that comprise cognitive maps.

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 Dates: 2022-01
 Publication Status: Submitted
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1101/2022.01.25.477716
 Degree: -

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