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  Biodiversity and vector-borne diseases: host dilution and vector amplification occur simultaneously for Amazonian leishmaniases

Kocher, A., Cornuault, J., Gantier, J.-C., Manzi, S., Chavy, A., Girod, R., et al. (2022). Biodiversity and vector-borne diseases: host dilution and vector amplification occur simultaneously for Amazonian leishmaniases. Molecular Ecology, 16341. doi:10.1111/mec.16341.

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 Creators:
Kocher, Arthur1, Author              
Cornuault, Josselin, Author
Gantier, Jean-Charles, Author
Manzi, Sophie, Author
Chavy, Agathe, Author
Girod, Romain, Author
Dusfour, Isabelle, Author
Forget, Pierre-Michel, Author
Ginouves, Marine, Author
Prévot, Ghislaine, Author
Guégan, Jean-François, Author
Bañuls, Anne-Laure, Author
de Thoisy, Benoît, Author
Murienne, Jérôme, Author
Affiliations:
1tide, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2591691              

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Free keywords: amplification effect, Culicidae, dilution effect, iDNA, metabarcoding, phlebotomine sand fly, zoonotic disease
 Abstract: Abstract Changes in biodiversity may impact infectious disease transmission through multiple mechanisms. We explored the impact of biodiversity changes on the transmission of Amazonian leishmaniases, a group of wild zoonoses transmitted by phlebotomine sand flies (Psychodidae), which represent an important health burden in a region where biodiversity is both rich and threatened. Using molecular analyses of sand fly pools and blood-fed dipterans, we characterized the disease system in forest sites in French Guiana undergoing different levels of human-induced disturbance. We show that the prevalence of Leishmania parasites in sand flies correlates positively with the relative abundance of mammal species known as Leishmania reservoirs. In addition, Leishmania reservoirs tend to dominate in less diverse mammal communities, in accordance with the dilution effect hypothesis. This results in a negative relationship between Leishmania prevalence and mammal diversity. On the other hand, higher mammal diversity is associated with higher sand fly density, possibly because more diverse mammal communities harbor higher biomass and more abundant feeding resources for sand flies, although more research is needed to identify the factors that shape sand fly communities. As a consequence of these antagonistic effects, decreased mammal diversity comes with an increase of parasite prevalence in sand flies, but has no detectable impact on the density of infected sand flies. These results represent additional evidence that biodiversity changes may simultaneously dilute and amplify vector-borne disease transmission through different mechanisms that need to be better understood before drawing generalities on the biodiversity-disease relationship.

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Language(s): eng - English
 Dates: 2022-01-09
 Publication Status: Published online
 Pages: 15
 Publishing info: -
 Table of Contents: 1 Introduction
2 Material and methods
2.1 Sampling
2.2 Laboratory
2.3 Bioinformatic analyses
2.4 Estimating mammal diversity from individual dipteran blood meals
2.5 Effect of mammal diversity on Leishmania transmission
3 Results
3.1 Sampling and molecular analyses
3.2 Sand fly, vertebrate and Leishmania
identifications
3.3 Statistical analyses
4 Discussion
 Rev. Type: Peer
 Identifiers: DOI: 10.1111/mec.16341
Other: shh3130
 Degree: -

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Title: Molecular Ecology
Source Genre: Journal
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Publ. Info: Oxford : Wiley-Blackwell
Pages: - Volume / Issue: - Sequence Number: 16341 Start / End Page: - Identifier: ISSN: 0962-1083
CoNE: https://pure.mpg.de/cone/journals/resource/954925580119