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  A literature review of magnetic resonance imaging sequence advancements in visualizing functional neurosurgery targets

Boutet, A., Loh, A., Chow, C. T., Taha, A., Elias, G. J. B., Neudorfer, C., et al. (2021). A literature review of magnetic resonance imaging sequence advancements in visualizing functional neurosurgery targets. Journal of Neurosurgery, 135(5), 1445-1458. doi:10.3171/2020.8.JNS201125.

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 Creators:
Boutet, Alexandre1, 2, Author
Loh, Aaron1, Author
Chow, Clement T.1, Author
Taha, Alaa1, Author
Elias, Gavin J. B.1, Author
Neudorfer, Clemens1, Author
Germann, Jurgen1, Author
Paff, Michelle1, Author
Zrinzo, Ludvic3, Author
Fasano, Alfonso4, 5, Author
Kalia, Suneil K.1, Author
Steele, Christopher6, 7, Author              
Mikulis, David1, 2, Author
Kucharczyk, Walter1, 2, Author
Lozano, Andres M.1, Author
Affiliations:
1University Health Network, University of Toronto, ON, Canada, ou_persistent22              
2Joint Department of Medical Imaging, University of Toronto, ON, Canada, ou_persistent22              
3Functional Neurosurgery Unit, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, United Kingdom, ou_persistent22              
4Morton and Gloria Shulman Movement Disorders Clinic, University Health Network, University of Toronto, ON, Canada, ou_persistent22              
5Krembil Brain Institute, University Health Network, University of Toronto, ON, Canada, ou_persistent22              
6Department of Psychology, Concordia University, Montréal, QC, Canada, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: MRI; Functional neurosurgery; Magnetic resonance imaging; Targets; Visualization
 Abstract: Objective: Historically, preoperative planning for functional neurosurgery has depended on the indirect localization of target brain structures using visible anatomical landmarks. However, recent technological advances in neuroimaging have permitted marked improvements in MRI-based direct target visualization, allowing for refinement of "first-pass" targeting. The authors reviewed studies relating to direct MRI visualization of the most common functional neurosurgery targets (subthalamic nucleus, globus pallidus, and thalamus) and summarize sequence specifications for the various approaches described in this literature. Methods: The peer-reviewed literature on MRI visualization of the subthalamic nucleus, globus pallidus, and thalamus was obtained by searching MEDLINE. Publications examining direct MRI visualization of these deep brain stimulation targets were included for review. Results: A variety of specialized sequences and postprocessing methods for enhanced MRI visualization are in current use. These include susceptibility-based techniques such as quantitative susceptibility mapping, which exploit the amount of tissue iron in target structures, and white matter attenuated inversion recovery, which suppresses the signal from white matter to improve the distinction between gray matter nuclei. However, evidence confirming the superiority of these sequences over indirect targeting with respect to clinical outcome is sparse. Future targeting may utilize information about functional and structural networks, necessitating the use of resting-state functional MRI and diffusion-weighted imaging. Conclusions: Specialized MRI sequences have enabled considerable improvement in the visualization of common deep brain stimulation targets. With further validation of their ability to improve clinical outcomes and advances in imaging techniques, direct visualization of targets may play an increasingly important role in preoperative planning.

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Language(s): eng - English
 Dates: 2021-03-262021-11
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3171/2020.8.JNS201125
Other: online ahead of print
PMID: 33770759
 Degree: -

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Title: Journal of Neurosurgery
  Other : J. Neurosurg.
Source Genre: Journal
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Affiliations:
Publ. Info: Rolling Meadows, Ill. [etc.] : American Association of Neurological Surgeons [etc.]
Pages: - Volume / Issue: 135 (5) Sequence Number: - Start / End Page: 1445 - 1458 Identifier: ISSN: 0022-3085
CoNE: https://pure.mpg.de/cone/journals/resource/111088196498180