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  Molecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 cases

Vasilevska, V., Guest, P. C., Bernstein, H.-G., Schroeter, M. L., Geis, C., & Steiner, J. (2021). Molecular mimicry of NMDA receptors may contribute to neuropsychiatric symptoms in severe COVID-19 cases. Journal of Neuroinflammation, 18(1): 245. doi:10.1186/s12974-021-02293-x.

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 Creators:
Vasilevska, Veronika1, Author
Guest, Paul C.2, Author
Bernstein, Hans-Gert1, Author
Schroeter, Matthias L.3, Author              
Geis, Christian4, 5, Author
Steiner, Johann1, 5, 6, Author
Affiliations:
1Laboratory of Translational Psychiatry, Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
2Laboratory of Neuroproteomics, Department of Biochemistry, Institute of Biology, State University of Campinas, Brazil, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Section Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Germany, ou_persistent22              
5Center for Intervention and Research On Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Magdeburg, Germany, ou_persistent22              
6Center for Behavioral Brain Sciences, Magdeburg, Germany, ou_persistent22              

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Free keywords: Autoimmune encephalitis; COVID-19; Corticosteroid; Immunomodulatory agent; Inflammation; NMDA receptor; SARS-CoV-2
 Abstract: Approximately 30% of individuals with severe SARS-CoV-2 infections also develop neurological and psychiatric complaints. In rare cases, the occurrence of autoimmune encephalitis has been reported after SARS-CoV-2 infection. In this systematic review, we have identified eight SARS-CoV-2-associated cases of anti-NMDA receptor encephalitis. All had cerebrospinal fluid antibodies against the NMDA receptor and a recent onset of working memory deficits, altered mental status, or psychiatric symptoms, such as confusion, agitation, auditory hallucination, catatonia and speech dysfunction. All patients received high-dose steroid and immunoglobulin therapeutics and conditions improved in each case. These findings suggest that clinical attention should be paid to warning signs of autoimmune encephalitis in severe COVID-19 cases. If characteristic features of autoimmune encephalitis are present, autoantibody diagnostics should be performed and confirmed cases should be treated with immunotherapy to minimize neurological impairments.

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Language(s): eng - English
 Dates: 2021-10-282021
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1186/s12974-021-02293-x
PMID: 34711233
PMC: PMC8551937
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Project name : -
Grant ID : 01EW2012
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Funding organization : European Research Area Network (ERA-NET)

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Title: Journal of Neuroinflammation
Source Genre: Journal
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Publ. Info: London : BioMed Central
Pages: - Volume / Issue: 18 (1) Sequence Number: 245 Start / End Page: - Identifier: ISSN: 1742-2094
CoNE: https://pure.mpg.de/cone/journals/resource/1742-2094