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  The Roles of the Virome in Cancer

Broecker, F., & Mölling, K. (2021). The Roles of the Virome in Cancer. Microorganisms, 9(12): 2538. doi:10.3390/microorganisms9122538.

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Genre: Journal Article

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microorganisms_BroeckerMoelling_2021.pdf (Publisher version), 3MB
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Microorganisms_Broecker and Moelling_2021.pdf
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© 2021 by the authors

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 Creators:
Broecker, Felix, Author
Mölling, Karin1, Author              
Affiliations:
1Emeritus Group of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2385697              

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Free keywords: virome; microbiota; cancer; bacteriophages; fecal microbiota transplantation; checkpoint inhibitors; immunotherapy
 Abstract: Viral infections as well as changes in the composition of the intestinal microbiota and virome have been linked to cancer. Moreover, the success of cancer immunotherapy with checkpoint inhibitors has been correlated with the intestinal microbial composition of patients. The transfer of feces—which contain mainly bacteria and their viruses (phages)—from immunotherapy responders to non-responders, known as fecal microbiota transplantation (FMT), has been shown to be able to convert some non-responders to responders. Since phages may also increase the response to immunotherapy, for example by inducing T cells cross-reacting with cancer antigens, modulating phage populations may provide a new avenue to improve immunotherapy responsiveness. In this review, we summarize the current knowledge on the human virome and its links to cancer, and discuss the potential utility of bacteriophages in increasing the responder rate for cancer immunotherapy.

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Language(s): eng - English
 Dates: 2021-12-062021-12-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3390/microorganisms9122538
 Degree: -

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Title: Microorganisms
Source Genre: Journal
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Publ. Info: Basel : MDPI
Pages: - Volume / Issue: 9 (12) Sequence Number: 2538 Start / End Page: - Identifier: ISSN: 2076-2607
CoNE: https://pure.mpg.de/cone/journals/resource/2076-2607