English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  The relationship between hippocampal-dependent task performance and hippocampal grey matter myelination and iron content

Clark, I. A., Callaghan, M. F., Weiskopf, N., & Maguire, E. A. (2021). The relationship between hippocampal-dependent task performance and hippocampal grey matter myelination and iron content. Brain and Neuroscience Advances. doi:10.1177/23982128211011923.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Clark_Callaghan_2021.pdf (Publisher version), 734KB
Name:
Clark_Callaghan_2021.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Clark, Ian A.1, Author
Callaghan, Martina F.1, Author
Weiskopf, Nikolaus1, 2, 3, Author              
Maguire, Eleanor A.1, Author
Affiliations:
1Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              

Content

show
hide
Free keywords: Hippocampus; Autobiographical memory; Future thinking; Iron; Myelin; Quantitative MRI; Scene construction; Spatial navigation; Tissue microstructure
 Abstract: Individual differences in scene imagination, autobiographical memory recall, future thinking and spatial navigation have long been linked with hippocampal structure in healthy people, although evidence for such relationships is, in fact, mixed. Extant studies have predominantly concentrated on hippocampal volume. However, it is now possible to use quantitative neuroimaging techniques to model different properties of tissue microstructure in vivo such as myelination and iron. Previous work has linked such measures with cognitive task performance, particularly in older adults. Here we investigated whether performance on scene imagination, autobiographical memory, future thinking and spatial navigation tasks was associated with hippocampal grey matter myelination or iron content in young, healthy adult participants. Magnetic resonance imaging data were collected using a multi-parameter mapping protocol (0.8 mm isotropic voxels) from a large sample of 217 people with widely-varying cognitive task scores. We found little evidence that hippocampal grey matter myelination or iron content were related to task performance. This was the case using different analysis methods (voxel-based quantification, partial correlations), when whole brain, hippocampal regions of interest, and posterior:anterior hippocampal ratios were examined, and across different participant sub-groups (divided by gender and task performance). Variations in hippocampal grey matter myelin and iron levels may not, therefore, help to explain individual differences in performance on hippocampal-dependent tasks, at least in young, healthy individuals.

Details

show
hide
Language(s): eng - English
 Dates: 2021-01-212021-04-012021-04-26
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1177/23982128211011923
Other: eCollection Jan-Dec 2021
PMID: 33997294
PMC: PMC8079931
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : 101759/Z/13/Z; 203147/Z/16/Z
Funding program : Wellcome Principal Research Fellowship
Funding organization : -
Project name : -
Grant ID : MR/R000050/1
Funding program : ERA-NET Neuron
Funding organization : -
Project name : -
Grant ID : FP7/2007-2013; 616905; 681094
Funding program : -
Funding organization : European Research Council
Project name : -
Grant ID : 01EW1711A & B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

Source 1

show
hide
Title: Brain and Neuroscience Advances
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Thousand Oaks : Sage
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 2398-2128
CoNE: https://pure.mpg.de/cone/journals/resource/2398-2128