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Free keywords:
low-affinity nerve growth factor receptor
neurotrophin
choline
acetyltransferase
immunohistochemistry
ngf receptor
immunohistochemical localization
acetyltransferase
activity
messenger-rna
neonatal rats
expression
system
neostriatum
nucleus
gene
Neurosciences & Neurology
Abstract:
Trk-immunoreactivity was observed in basal forebrain and striatal cholinergic neurons, whereas low-affinity NGF receptor immunoreactivity was observed in basal forebrain but not striatal cholinergic neurons. Since NGF exerts trophic actions on both basal forebrain and striatal cholinergic populations, the presence of Trk in these neurons lends strong support for an essential role of Trk in NGF-responsive neurons, but suggests that the low affinity receptor is not necessary for NGF actions in the striatum.
