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  The menstrual cycle modulates whole-brain turbulent dynamics

De Filippi, E., Uribe, C., Avila-Varela, D. S., Martínez-Molina, N., Gashaj, V., Pritschet, L., et al. (2021). The menstrual cycle modulates whole-brain turbulent dynamics. Frontiers in Neuroscience, 15: 753820. doi:10.3389/fnins.2021.753820.

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 Creators:
De Filippi, Eleonora1, Author
Uribe, Carme2, 3, Author
Avila-Varela, Daniela S.4, Author
Martínez-Molina, Noelia1, Author
Gashaj, Venera1, 5, Author
Pritschet, Laura6, Author
Santander, Tyler6, Author
Jacobs, Emily G.7, Author
Kringelbach, Morten L.8, 9, 10, Author
Sanz Perl, Yonatan1, Author
Deco, Gustavo1, 11, 12, 13, Author              
Escrichs, Anira1, Author
Affiliations:
1Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Campbell Family Mental Health Research Institute, Department of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, ON, Canada, ou_persistent22              
3Medical Psychology Unit, Department of Medicine, University of Barcelona, Spain, ou_persistent22              
4Speech Acquisition and Perception Group, Department of Technology, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
5Swiss Federal Institute of Technology, Zurich, Switzerland, ou_persistent22              
6Department of Psychological and Brain Sciences, University of California Santa Barbara, CA, USA, ou_persistent22              
7Neuroscience Research Institute, University of California Santa Barbara, CA, USA, ou_persistent22              
8Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
9Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
10Department of Clinical Medicine, Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
11Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
12Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
13Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: Brain information processing; Menstrual cycle; Resting-state fMRI; Turbulence; Whole-brain dynamics
 Abstract: Brain dynamics have recently been shown to be modulated by rhythmic changes in female sex hormone concentrations across an entire menstrual cycle. However, many questions remain regarding the specific differences in information processing across spacetime between the two main follicular and luteal phases in the menstrual cycle. Using a novel turbulent dynamic framework, we studied whole-brain information processing across spacetime scales (i.e., across long and short distances in the brain) in two open-source, dense-sampled resting-state datasets. A healthy naturally cycling woman in her early twenties was scanned over 30 consecutive days during a naturally occurring menstrual cycle and under a hormonal contraceptive regime. Our results indicated that the luteal phase is characterized by significantly higher information transmission across spatial scales than the follicular phase. Furthermore, we found significant differences in turbulence levels between the two phases in brain regions belonging to the default mode, salience/ventral attention, somatomotor, control, and dorsal attention networks. Finally, we found that changes in estradiol and progesterone concentrations modulate whole-brain turbulent dynamics in long distances. In contrast, we reported no significant differences in information processing measures between the active and placebo phases in the hormonal contraceptive study. Overall, the results demonstrate that the turbulence framework is able to capture differences in whole-brain turbulent dynamics related to ovarian hormones and menstrual cycle stages.

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Language(s): eng - English
 Dates: 2021-08-052021-11-112021-12-09
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnins.2021.753820
Other: eCollection 2021
PMID: 34955718
PMC: PMC8695489
 Degree: -

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Grant ID : 945539
Funding program : Human Brain Project
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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 15 Sequence Number: 753820 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548