The in vivo hydrocarbon formation by vanadium nitrogenase follows a secondary 
metabolic pathway

Rebelein, Johannes G.; Lee, Chi Chung; Hu, Yilin; Ribbe, Markus W.

doi:10.1038/ncomms13641

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The in vivo hydrocarbon formation by vanadium nitrogenase follows a secondary metabolic pathway

Rebelein, J. G., Lee, C. C., Hu, Y., & Ribbe, M. W. (2016). The in vivo hydrocarbon formation by vanadium nitrogenase follows a secondary metabolic pathway. NATURE COMMUNICATIONS, 7: 13641. doi:10.1038/ncomms13641.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-EC7A-5 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-EC7B-4

Genre: Journal Article

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Creators:
Rebelein, Johannes G.¹, Author
Lee, Chi Chung², Author
Hu, Yilin², Author
Ribbe, Markus W.², Author

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1University of California, Irvine, California, USA, ou_persistent22
2external, ou_persistent22

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Abstract: The vanadium (V)-nitrogenase of Azotobacter vinelandii catalyses the in vitro conversion of carbon monoxide (CO) to hydrocarbons. Here we show that an A. vinelandii strain expressing the V-nitrogenase is capable of in vivo reduction of CO to ethylene (C2H4), ethane (C2H6) and propane (C3H8). Moreover, we demonstrate that CO is not used as a carbon source for cell growth, being instead reduced to hydrocarbons in a secondary metabolic pathway. These findings suggest a possible role of the ancient nitrogenase as an evolutionary link between the carbon and nitrogen cycles on Earth and establish a solid foundation for biotechnological adaptation of a whole-cell approach to recycling carbon wastes into hydrocarbon products. Thus, this study has several repercussions for evolution-, environment- and energy-related areas.

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Dates: Published Online: 2016

Publication Status: Published online

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Identifiers: ISI: 000390283000001
DOI: 10.1038/ncomms13641

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Title: NATURE COMMUNICATIONS

Source Genre: Journal

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Pages: - Volume / Issue: 7 Sequence Number: 13641 Start / End Page: - Identifier: ISSN: 2041-1723