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  Coherent theta oscillations in the cerebellum and supplementary motor area mediate visuomotor adaptation

Tzvi, E., Gajiyeva, L., Bindel, L., Hartwigsen, G., & Classen, J. (2022). Coherent theta oscillations in the cerebellum and supplementary motor area mediate visuomotor adaptation. NeuroImage, 251: 118985. doi:10.1016/j.neuroimage.2022.118985.

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 Creators:
Tzvi, Elinor1, Author
Gajiyeva, Leila2, Author
Bindel, Laura1, Author
Hartwigsen, Gesa2, Author              
Classen, Joseph1, Author
Affiliations:
1Department of Neurology, University Hospital Leipzig, Germany, ou_persistent22              
2Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              

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 Abstract: The cerebellum and its interaction with cortical areas play a key role in our ability to flexibly adapt a motor program in response to sensory input. Current knowledge about specific neural mechanisms underlying the process of visuomotor adaptation is however lacking. Using a novel placement of EEG electrodes to record electric activity from the cerebellum, we studied local cerebellar activity, as well as its coupling with neocortical activity to obtain direct neurophysiological markers of visuomotor adaptation in humans. We found increased theta (4-8 Hz) power in "cerebellar" as well as cortical electrodes, when subjects first encountered a visual manipulation. Theta power decreased as subjects adapted to the perturbation, and rebounded when the manipulation was suddenly removed. This effect was observed in two distinct locations: a cerebellar cluster and a central cluster, which were localized in left cerebellar crus I (lCB) and right supplementary motor area (rSMA) using linear constrained minimum variance beamforming. Importantly, we found that better adaptation was associated with increased theta power in left cerebellar electrodes and a right sensorimotor cortex electrode. Finally, increased rSMA -> lCB connectivity was significantly decreased with adaptation. These results demonstrate that: (1) cerebellar theta power is markedly modulated over the course of visuomotor adaptation and (2) theta oscillations could serve as a key mechanism for communication within a cortico-cerebellar loop.

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Language(s): eng - English
 Dates: 2022-01-252021-10-212022-02-072022-02-082022-05-01
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.118985
Other: epub 2022
PMID: 35149228
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 251 Sequence Number: 118985 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166