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  Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age

Ballarini, T., Melo van Lent, D., Brunner, J., Schröder, A., Wolfsgruber, S., Altenstein, S., et al. (2021). Mediterranean Diet, Alzheimer Disease Biomarkers and Brain Atrophy in Old Age. Neurology, 96(24), e2920-e2932. doi:10.1212/WNL.0000000000012067.

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Ballarini, T, Author
Melo van Lent, D, Author
Brunner, J, Author
Schröder, A, Author
Wolfsgruber, S, Author
Altenstein, S, Author
Brosseron, F, Author
Buerger, K, Author
Dechent, P, Author
Dobisch, L, Author
Ertl-Wagner, B, Author
Fliessbach, K, Author
Freiesleben, SD, Author
Frommann, I, Author
Glanz, W, Author
Hauser, D, Author
Haynes, JD, Author
Heneka, MT, Author
Janowitz, D, Author
Kilimann, I, Author
Laske, C, AuthorMaier, F, AuthorMetzger, CD, AuthorMunk, M, Author              Perneczky, R, AuthorPeters, O, AuthorPriller, J, AuthorRamirez, A, AuthorRauchmann, B, AuthorRoy, N, AuthorScheffler, K1, 2, Author              Schneider, A, AuthorSpottke, A, AuthorSpruth, EJ, AuthorTeipel, SJ, AuthorVukovich, R, AuthorWiltfang, J, AuthorJessen, F, AuthorWagner, M, Author more..
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Objective: To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer's disease (AD), we analyzed cross-sectional data from the German Longitudinal Cognitive Impairment and Dementia Study METHOD: The sample (n=512, mean age: 69.5±5.9 years) included 169 cognitively normal participants and subjects at higher AD risk (53 AD relatives, 209 SCD and 81 MCI). We defined MeDi adherence based on the Food Frequency Questionnaire. Brain volume outcomes were generated via voxel-based morphometry on T1-MRI and cognitive performance with an extensive neuropsychological battery. AD-related biomarkers (Aβ42/40 ratio, pTau181) in cerebrospinal fluid were assessed in n=226 individuals. We analyzed the associations between MeDi and the outcomes with linear regression models controlling for several covariates. Additionally, we applied hypothesis-driven mediation and moderation analysis. Results: Higher MeDi adherence related to larger mediotemporal gray matter volume (p<0.05 FWE corrected), better memory (β±SE = 0.03 ± 0.02; p=0.038), and less amyloid (Aβ42/40 ratio, β±SE = 0.003 ± 0.001; p=0.008) and pTau181 pathology (β±SE = -1.96±0.68; p=0.004). Mediotemporal volume mediated the association between MeDi and memory (40% indirect mediation). Finally, MeDi favorably moderated the associations between Aβ42/40 ratio, pTau181 and mediotemporal atrophy. Results were consistent correcting for ApoE-ε4 status. Conclusion: Our findings corroborate the view of MeDi as a protective factor against memory decline and mediotemporal atrophy. Importantly, they suggest that these associations might be explained by a decrease of amyloidosis and tau-pathology. Longitudinal and dietary intervention studies should further examine this conjecture and its treatment implications.

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 Dates: 2021-05
 Publication Status: Published in print
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 Rev. Type: -
 Identifiers: DOI: 10.1212/WNL.0000000000012067
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Title: Neurology
Source Genre: Journal
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Publ. Info: Cleveland, Ohio [etc.] : Advanstar Communications [etc.]
Pages: - Volume / Issue: 96 (24) Sequence Number: - Start / End Page: e2920 - e2932 Identifier: ISSN: 0028-3878
CoNE: https://pure.mpg.de/cone/journals/resource/954925246073