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  Mitosis-promoting factor-mediated suppression of a cloned delayed rectifier potassium channel expressed in Xenopus oocytes

Bruggemann, A., Stuhmer, W., & Pardo, L. A. (1997). Mitosis-promoting factor-mediated suppression of a cloned delayed rectifier potassium channel expressed in Xenopus oocytes. Proc Natl Acad Sci U S A, 94(2), 537-42. doi:10.1073/pnas.94.2.537.

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Genre: Journal Article

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 Creators:
Bruggemann, A.1, Author
Stuhmer, W.1, Author
Pardo, L. A.1, Author
Affiliations:
1Max Planck Society, ou_persistent13              

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Free keywords: Animals Cyclins/physiology Electric Conductivity Ether-A-Go-Go Potassium Channels Ion Channel Gating Maturation-Promoting Factor/*physiology Membrane Potentials Oocytes Potassium Channels/*physiology Progesterone/pharmacology Signal Transduction Spermine/pharmacology Time Factors Xenopus laevis
 Abstract: The cell cycle is the crucial process that leads to mitosis in all cell types. The dramatic redirectioning of many cellular processes during the cycle is known to involve ion channels, either changing their level of expression or their voltage dependence, as in the case of inward rectifiers. Here we describe the specific inhibition of heterologously expressed ionic channels at the onset of maturation in Xenopus oocytes. In cells expressing rat eag (R-eag) potassium channels, maturation induces a dramatic reduction in the current amplitude, which is almost complete in most cases. The key molecule in oocyte maturation, the mitosis-promoting factor (a complex of cyclin B and p34cdc2), is able to induce similar changes when injected into the oocytes.

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Language(s): eng - English
 Dates: 1997-01-211997-01-21
 Publication Status: Published in print
 Pages: -
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 Rev. Type: -
 Identifiers: Other: 9012819
DOI: 10.1073/pnas.94.2.537
ISSN: 0027-8424 (Print) 0027-8424 (Linking)
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Title: Proc Natl Acad Sci U S A
  Alternative Title : Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Pages: - Volume / Issue: 94 (2) Sequence Number: - Start / End Page: 537 - 42 Identifier: -