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Free keywords:
Animals
CHO Cells
Cricetinae
Ether-A-Go-Go Potassium Channels
Glycosylation
Potassium Channels/chemistry/*physiology
Protein Processing, Post-Translational
Protein Transport
Xenopus
Abstract:
N-Linked glycosylation is a common post-translational modification of membrane proteins. Here we report that mature Eag1 potassium channels carry sugar moieties linked to asparagines at positions 388 and 406. Asn-388 seems to undergo only core glycosylation, but complex sugars are bound to Asn-406. Correct complex glycosylation is required for proper trafficking of Eag1 to the plasma membrane but is also crucial for the correct function of channels already inserted in the membrane.
