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  Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia

Barrantes-Freer, A., Kim, E., Bielanska, J., Giese, A., Mortensen, L. S., Schulz-Schaeffer, W. J., et al. (2013). Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia. J Neuropathol Exp Neurol, 72(4), 307-24. doi:10.1097/NEN.0b013e31828afdbd.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0009-F23F-0 Version Permalink: https://hdl.handle.net/21.11116/0000-0009-F240-D
Genre: Journal Article

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 Creators:
Barrantes-Freer, A.1, Author
Kim, E.1, Author
Bielanska, J.1, Author
Giese, A.1, Author
Mortensen, L. S.1, Author
Schulz-Schaeffer, W. J.1, Author
Stadelmann, C.1, Author
Bruck, W.1, Author
Pardo, L. A.1, Author
Affiliations:
1Max Planck Society, ou_persistent13              

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Free keywords: Animals Brain Neoplasms/chemistry/ genetics/ pathology Cell Line, Tumor Cells, Cultured Glioma/chemistry/ genetics/ pathology Humans Immunophenotyping Membrane Potentials/genetics Mice Neuroglia/pathology/ physiology Tumor Cells, Cultured
 Abstract: Glioma-initiating cells (GICs) represent a potential important therapeutic target because they are likely to account for the frequent recurrence of malignant gliomas; however, their identity remains unsolved. Here, we characterized the cellular lineage fingerprint of GICs through a combination of electrophysiology, lineage marker expression, and differentiation assays of 5 human patient-derived primary GIC lines. Most GICs coexpressed nestin, NG2 proteoglycan, platelet-derived growth factor receptor-alpha, and glial fibrillary acidic protein. Glioma-initiating cells could be partially differentiated into astrocytic but not oligodendroglial or neural lineages. We also demonstrate that GICs have a characteristic electrophysiologic profile distinct from that of well-characterized tumor bulk cells. Together, our results suggest that GICs represent a unique type of cells reminiscent of an immature phenotype that closely resembles but is not identical to NG2 glia with respect to marker expression and functional membrane properties.

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Language(s): eng - English
 Dates: 2013-042013-03-14
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: 23481707
DOI: 10.1097/NEN.0b013e31828afdbd
ISSN: 1554-6578 (Electronic) 0022-3069 (Linking)
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Title: J Neuropathol Exp Neurol
Source Genre: Journal
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Pages: - Volume / Issue: 72 (4) Sequence Number: - Start / End Page: 307 - 24 Identifier: -