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  Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline

Hansen, N., Singh, A., Bartels, C., Brosseron, F., Buerger, K., Cetindag, A., et al. (2021). Hippocampal and Hippocampal-Subfield Volumes From Early-Onset Major Depression and Bipolar Disorder to Cognitive Decline. Frontiers in Aging Neuroscience, 13: 626974, pp. 1-12. doi:10.3389/fnagi.2021.626974.

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 Creators:
Hansen, N, Author
Singh, A, Author
Bartels, C, Author
Brosseron, F, Author
Buerger, K, Author
Cetindag , AC, Author
Dobisch, L, Author
Dechent, P, Author
Ertl-Wagner, BB, Author
Fliessbach, K, Author
Haynes, JD, Author
Heneka, MT, Author
Janowitz, D, Author
Kilimann, I, Author
Laske, C, Author
Metzger, CD, Author
Munk, MH, Author              
Peters, O, Author
Priller, J, Author
Roy, N, Author
Scheffler, K1, 2, Author              Schneider, A, AuthorSpottke, A, AuthorSpruth, EJ, AuthorTeipel, S, AuthorTscheuschler, M, AuthorVukovich, R, AuthorWiltfang, J, AuthorDuezel, E, AuthorJessen, F, AuthorGoya-Maldonado, R, Author more..
Affiliations:
1Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
2Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: Background: The hippocampus and its subfields (HippSub) are reported to be diminished in patients with Alzheimer's disease (AD), bipolar disorder (BD), and major depressive disorder (MDD). We examined these groups vs healthy controls (HC) to reveal HippSub alterations between diseases. Methods: We segmented 3T-MRI T2-weighted hippocampal images of 67 HC, 58 BD, and MDD patients from the AFFDIS study and 137 patients from the DELCODE study assessing cognitive decline, including subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI), and AD, via Free Surfer 6.0 to compare volumes across groups. Results: Groups differed significantly in several HippSub volumes, particularly between patients with AD and mood disorders. In comparison to HC, significant lower volumes appear in aMCI and AD groups in specific subfields. Smaller volumes in the left presubiculum are detected in aMCI and AD patients, differing from the BD group. A significant linear regression is seen between left hippocampus volume and duration since the first depressive episode. Conclusions: HippSub volume alterations were observed in AD, but not in early-onset MDD and BD, reinforcing the notion of different neural mechanisms in hippocampal degeneration. Moreover, duration since the first depressive episode was a relevant factor explaining the lower left hippocampal volumes present in groups.

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 Dates: 2021-04
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.3389/fnagi.2021.626974
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Title: Frontiers in Aging Neuroscience
  Abbreviation : Front Aging Neurosci
Source Genre: Journal
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Publ. Info: Lausanne : Frontiers Research Foundation
Pages: - Volume / Issue: 13 Sequence Number: 626974 Start / End Page: 1 - 12 Identifier: ISSN: 1663-4365
CoNE: https://pure.mpg.de/cone/journals/resource/1663-4365