Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Cryogenic infrared spectroscopy provides mechanistic insight into the fragmentation of phospholipid silver adducts

Kirschbaum, C., Greis, K., Gewinner, S., Schöllkopf, W., Meijer, G., Helden, G. v., et al. (2022). Cryogenic infrared spectroscopy provides mechanistic insight into the fragmentation of phospholipid silver adducts. Analytical and Bioanalytical Chemistry, 414(18), 5275-5285. doi:10.1007/s00216-022-03927-6.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Dateien

einblenden: Dateien
ausblenden: Dateien
:
Kirschbaum2022_Article_CryogenicInfraredSpectroscopyP.pdf (Verlagsversion), 2MB
Name:
Kirschbaum2022_Article_CryogenicInfraredSpectroscopyP.pdf
Beschreibung:
-
OA-Status:
Hybrid
Sichtbarkeit:
Öffentlich
MIME-Typ / Prüfsumme:
application/pdf / [MD5]
Technische Metadaten:
Copyright Datum:
2022
Copyright Info:
The Author(s)

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Kirschbaum, Carla1, 2, Autor           
Greis, Kim1, 2, Autor           
Gewinner, Sandy2, Autor           
Schöllkopf, Wieland2, Autor           
Meijer, Gerard2, Autor           
Helden, Gert von2, Autor           
Pagel, Kevin1, 2, Autor           
Affiliations:
1Institut für Chemie und Biochemie, Freie Universität Berlin, 14195, Berlin, Germany, ou_persistent22              
2Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              

Inhalt

einblenden:
ausblenden:
Schlagwörter: Infrared spectroscopy; Tandem mass spectrometry; Lipidomics; Glycerophospholipids; Isomers; Silver
 Zusammenfassung: Tandem mass spectrometry is arguably the most important analytical tool for structure elucidation of lipids and other metabolites. By fragmenting intact lipid ions, valuable structural information such as the lipid class and fatty acyl composition are readily obtainable. The information content of a fragment spectrum can often be increased by the addition of metal cations. In particular, the use of silver ions is deeply rooted in the history of lipidomics due to their propensity to coordinate both electron-rich heteroatoms and C = C bonds in aliphatic chains. Not surprisingly, coordination of silver ions was found to enable the distinction of sn-isomers in glycerolipids by inducing reproducible intensity differences in the fragment spectra, which could, however, not be rationalized. Here, we investigate the fragmentation behaviors of silver-adducted sn- and double bond glycerophospholipid isomers by probing fragment structures using cryogenic gas-phase infrared (IR) spectroscopy. Our results confirm that neutral headgroup loss from silver-adducted glycerophospholipids leads to dioxolane-type fragments generated by intramolecular cyclization. By combining high-resolution IR spectroscopy and computational modelling of silver-adducted fragments, we offer qualitative explanations for different fragmentation behaviors of glycerophospholipid isomers. Overall, the results demonstrate that gas-phase IR spectroscopy of fragment ions can significantly contribute to our understanding of lipid dissociation mechanisms and the influence of coordinating cations.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2021-11-222022-01-252022-02-112022-07
 Publikationsstatus: Erschienen
 Seiten: 11
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1007/s00216-022-03927-6
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden: ausblenden:
Projektname : GlycoSpec - Unravelling Glycochemistry with Ion Mobility Spectrometry and Gas-Phase Spectroscopy
Grant ID : 863934
Förderprogramm : Horizon 2020 (H2020)
Förderorganisation : European Commission (EC)

Quelle 1

einblenden:
ausblenden:
Titel: Analytical and Bioanalytical Chemistry
  Kurztitel : Anal. Bioanal. Chem.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Heidelberg : Springer-Verlag
Seiten: 11 Band / Heft: 414 (18) Artikelnummer: - Start- / Endseite: 5275 - 5285 Identifikator: ISSN: 1618-2642
CoNE: https://pure.mpg.de/cone/journals/resource/111006469468428