Help Privacy Policy Disclaimer
  Advanced SearchBrowse


  Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., et al. (2021). Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group. MOLECULAR PSYCHIATRY, 26(8), 3884-3895. doi:10.1038/s41380-019-0605-z.

Item is


show Files




Jia, Tianye, Author
Chu, Congying, Author
Liu, Yun, Author
van Dongen, Jenny, Author
Papastergios, Evangelos, Author
Armstrong, Nicola J., Author
Bastin, Mark E., Author
Carrillo Roa, Tania1, Author           
den Braber, Anouk, Author
Harris, Mathew, Author
Jansen, Rick, Author
Liu, Jingyu, Author
Luciano, Michelle, Author
Ori, Anil P. S., Author
Santianez, Roberto Roiz, Author
Ruggeri, Barbara, Author
Sarkisyan, Daniil, Author
Shin, Jean, Author
Sungeun, Kim, Author
Gutierrez, Diana Tordesillas, Author
van't Ent, Dennis, AuthorAmes, David, AuthorArtiges, Eric, AuthorBakalkin, Georgy, AuthorBanaschewski, Tobias, AuthorBokde, Arun L. W., AuthorBrodaty, Henry, AuthorBromberg, Uli, AuthorBrouwer, Rachel, AuthorBuchel, Christian, AuthorQuinlan, Erin Burke, AuthorCahn, Wiepke, Authorde Zubicaray I, Greig, AuthorEhrlich, Stefan, AuthorEkstrom, Tomas J., AuthorFlor, Herta, AuthorFrohner, Juliane H., AuthorFrouin, Vincent, AuthorGaravan, Hugh, AuthorGowland, Penny, AuthorHeinz, Andreas, AuthorHoare, Jacqueline, AuthorIttermann, Bernd, AuthorJahanshad, Neda, AuthorJiang, Jiyang, AuthorKwok, John B., AuthorMartin, Nicholas G., AuthorMartinot, Jean-Luc, AuthorMather, Karen A., AuthorMcMahon, Katie L., AuthorMcRae, Allan F., AuthorNees, Frauke, AuthorOrfanos, Dimitri Papadopoulos, AuthorPaus, Tomas, AuthorPoustka, Luise, AuthorSamann, Philipp G.2, Author           Schofield, Peter R., AuthorSmolka, Michael N., AuthorStein, Dan J., AuthorStrike, Lachlan T., AuthorTeeuw, Jalmar, AuthorThalamuthu, Anbupalam, AuthorTrollor, Julian, AuthorWalter, Henrik, AuthorWardlaw, Joanna M., AuthorWen, Wei, AuthorWhelan, Robert, AuthorApostolova, Liana G., AuthorBinder, Elisabeth B.1, Author           Boomsma I, Dorret, AuthorCalhoun, Vince, AuthorCrespo-Facorro, Benedicto, AuthorDeary, Ian J., AuthorPol, Hilleke Hulshoff, AuthorOphoff, Roel A., AuthorPausova, Zdenka, AuthorSachdev, Perminder S., AuthorSaykin, Andrew, AuthorWright, Margaret J., AuthorThompson, Paul M., AuthorSchumann, Gunter, AuthorDesrivieres, Sylvane, Author more..
1Dept. Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Max Planck Society, ou_2035295              
2Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              


Free keywords: -
 Abstract: DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)-three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.


 Dates: 2021
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000731712800020
DOI: 10.1038/s41380-019-0605-z
 Degree: -



Legal Case


Project information


Source 1

Source Genre: Journal
Publ. Info: -
Pages: - Volume / Issue: 26 (8) Sequence Number: - Start / End Page: 3884 - 3895 Identifier: ISSN: 1359-4184