English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease

Domenighetti, C., Sugier, P.-E., Sreelatha, A. A. K., Schulte, C., Grover, S., Mohamed, O., et al. (2022). Mendelian Randomisation Study of Smoking, Alcohol, and Coffee Drinking in Relation to Parkinson's Disease. JOURNAL OF PARKINSONS DISEASE, 12(1), 267-282. doi:10.3233/JPD-212851.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Domenighetti, Cloe, Author
Sugier, Pierre-Emmanuel, Author
Sreelatha, Ashwin Ashok Kumar, Author
Schulte, Claudia, Author
Grover, Sandeep, Author
Mohamed, Oceane, Author
Portugal, Berta, Author
May, Patrick, Author
Bobbili, Dheeraj R., Author
Radivojkov-Blagojevic, Milena, Author
Lichtner, Peter, Author
Singleton, Andrew B., Author
Hernandez, Dena G., Author
Edsall, Connor, Author
Mellick, George D., Author
Zimprich, Alexander, Author
Pirker, Walter, Author
Rogaeva, Ekaterina, Author
Lang, Anthony E., Author
Koks, Sulev, Author
Taba, Pille, AuthorLesage, Suzanne, AuthorBrice, Alexis, AuthorCorvol, Jean-Christophe, AuthorChartier-Harlin, Marie-Christine, AuthorMutez, Eugenie, AuthorBrockmann, Kathrin, AuthorDeutschlaender, Angela B.1, Author           Hadjigeorgiou, Georges M., AuthorDardiotis, Efthimos, AuthorStefanis, Leonidas, AuthorSimitsi, Athina Maria, AuthorValente, Enza Maria, AuthorPetrucci, Simona, AuthorDuga, Stefano, AuthorStraniero, Letizia, AuthorZecchinelli, Anna, AuthorPezzoli, Gianni, AuthorBrighina, Laura, AuthorFerrarese, Carlo, AuthorAnnesi, Grazia, AuthorQuattrone, Andrea, AuthorGagliardi, Monica, AuthorMatsuo, Hirotaka, AuthorKawamura, Yusuke, AuthorHattori, Nobutaka, AuthorNishioka, Kenya, AuthorChung, Sun Ju, AuthorKim, Yun Joong, AuthorKolber, Pierre, Authorvan de Warrenburg, Bart Pc, AuthorBloem, Bastiaan R., AuthorAasly, Jan, AuthorToft, Mathias, AuthorPihlstrom, Lasse, AuthorGuedes, Leonor Correia, AuthorFerreira, Joaquim J., AuthorBardien, Soraya, AuthorCarr, Jonathan, AuthorTolosa, Eduardo, AuthorEzquerra, Mario, AuthorPastor, Pau, AuthorDiez-Fairen, Monica, AuthorWirdefeldt, Karin, AuthorPedersen, Nancy L., AuthorRan, Caroline, AuthorBelin, Andrea C., AuthorPuschmann, Andreas, AuthorHellberg, Clara, AuthorClarke, Carl E., AuthorMorrison, Karen E., AuthorTan, Manuela, AuthorKrainc, Dimitri, AuthorBurbulla, Lena F., AuthorFarrer, Matt J., AuthorKrueger, Rejko, AuthorGasser, Thomas, AuthorSharma, Manu, AuthorElbaz, Alexis, Author more..
Affiliations:
1Max Planck Institute of Psychiatry, Max Planck Society, ou_1607137              

Content

show
hide
Free keywords: -
 Abstract: Background: Previous studies showed that lifestyle behaviors (cigarette smoking, alcohol, coffee) are inversely associated with Parkinson's disease (PD). The prodromal phase of PD raises the possibility that these associations may be explained by reverse causation.
Objective: To examine associations of lifestyle behaviors with PD using two-sample Mendelian randomisation (MR) and the potential for survival and incidence-prevalence biases.
Methods: We used summary statistics from publicly available studies to estimate the association of genetic polymorphisms with lifestyle behaviors, and from Courage-PD (7,369 cases, 7,018 controls; European ancestry) to estimate the association of these variants with PD. We used the inverse-variance weighted method to compute odds ratios (ORIVW ) of PD and 95% confidence intervals (CI). Significance was determined using a Bonferroni-corrected significance threshold (p = 0.017).
Results: We found a significant inverse association between smoking initiation and PD (OR(IVW )per 1-SD increase in the prevalence of ever smoking = 0.74, 95%CI = 0.60-0.93, p = 0.009) without significant directional pleiotropy. Associations in participants <= 67 years old and cases with disease duration <= 7 years were of a similar size. No significant associations were observed for alcohol and coffee drinking. In reverse MR, genetic liability toward PD was not associated with smoking or coffee drinking but was positively associated with alcohol drinking.
Conclusion: Our findings are in favor of an inverse association between smoking and PD that is not explained by reverse causation, confounding, and survival or incidence-prevalence biases. Genetic liability toward PD was positively associated with alcohol drinking. Conclusions on the association of alcohol and coffee drinking with PD are hampered by insufficient statistical power.

Details

show
hide
Language(s):
 Dates: 2022
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000747072700020
DOI: 10.3233/JPD-212851
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: JOURNAL OF PARKINSONS DISEASE
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 12 (1) Sequence Number: - Start / End Page: 267 - 282 Identifier: ISSN: 1877-7171