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  Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions

Keliris, G., Shao, Y., Schmid, M., Augath, M., Logothetis, N., & Smirnakis, S. (2022). Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions. Frontiers in Neuroscience, 16: 757091. doi:10.3389/fnins.2022.757091.

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 Creators:
Keliris, GA1, 2, Author              
Shao, Y1, 2, Author              
Schmid, MC1, 2, Author              
Augath, M1, 2, Author              
Logothetis, NK1, 2, Author              
Smirnakis, SM, Author              
Affiliations:
1Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497798              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: In the adult visual system, topographic reorganization of the primary visual cortex (V1) after retinal lesions has been extensively investigated. In contrast, the plasticity of higher order extrastriate areas following retinal lesions is less well studied. Here, we used fMRI to study reorganization of visual areas V2/V3 following the induction of permanent, binocular, homonymous retinal lesions in 4 adult macaque monkeys. We found that the great majority of voxels that did not show visual modulation on the day of the lesion in the V2/V3 lesion projection zone (LPZ) demonstrated significant visual modulations 2 weeks later, and the mean modulation strength remained approximately stable thereafter for the duration of our observations (4-5 months). The distribution of eccentricities of visually modulated voxels inside the V2/V3 LPZ spanned a wider range post-lesion than pre-lesion, suggesting that neurons inside the LPZ reorganize by receiving input either from the foveal or the peripheral border of the LPZ, depending on proximity. Overall, we conclude that area V2/V3 of adult rhesus macaques displays a significant capacity for topographic reorganization following retinal lesions markedly exceeding the corresponding capacity of area V1.

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 Dates: 2022-01
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.3389/fnins.2022.757091
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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: 11 Volume / Issue: 16 Sequence Number: 757091 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548