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  Resolution of diaschisis contributes to early recovery from post-stroke aphasia

Wawrzyniak, M., Schneider, H., Klingbeil, J., Stockert, A., Hartwigsen, G., Weiller, C., et al. (2022). Resolution of diaschisis contributes to early recovery from post-stroke aphasia. NeuroImage, 251: 119001. doi:10.1016/j.neuroimage.2022.119001.

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 Creators:
Wawrzyniak, Max1, Author
Schneider, Hans1, Author
Klingbeil, Julian1, Author
Stockert, Anika1, Author
Hartwigsen, Gesa2, Author              
Weiller, Cornelius3, Author
Saur, Dorothee1, Author
Affiliations:
1Language & Aphasia Laboratory, Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
2Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              
3Freiburg Brain Imaging, University Medical Center, Germany, ou_persistent22              

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Free keywords: Aphasia; Connectivity; Diaschisis; Recovery; Stroke; fMRI
 Abstract: Diaschisis is a phenomenon observed in stroke that is defined as neuronal dysfunction in regions spared by the infarction but connected to the lesion site. We combined lesion network mapping and task-based functional MRI in 71 patients with post-stroke aphasia to investigate, whether diaschisis and its resolution contribute to early loss and recovery of language functions. Language activation acquired in the acute, subacute and chronic phase was analyzed in compartments with high and low normative resting-state functional connectivity to the lesion site on an individual basis. Regions with high compared to regions with low lesion connectivity showed a steeper increase in language reactivation from the acute to the subacute phase. This finding is compatible with the assumption of resolution of diaschisis. Additionally, language performance in the subacute phase and improvement from the subacute to the chronic phase significantly correlated with the diaschisis effect and its resolution, respectively, suggesting a behavioral relevance of this effect. We therefore assume that undamaged but functionally connected regions become dysfunctional due to missing input from the lesion contributing to the aphasic deficit. Since these regions are structurally intact, dysfunction resolves over time contributing to the rapid early behavioral improvement observed in aphasic stroke patients. Our results demonstrate that diaschisis and its resolution might be a relevant mechanism of early loss and recovery of language function in acute stroke patients.

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Language(s): eng - English
 Dates: 2022-01-312021-04-092022-02-122022-02-132022-05-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.119001
Other: epub 2022
PMID: 35172200
 Degree: -

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 251 Sequence Number: 119001 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166