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キーワード:
neural activity
neuronal-activity
prey capture
2-photon excitation
action-potentials
gene-expression
optical control
ground plan
in-vivo
cells
Neurosciences & Neurology
要旨:
Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system. Here we review recent work in which these new tools have been applied to zebrafish, and discuss some of the existing challenges of these approaches.
