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  Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity

Zhao, L., Vo, T. D., Kaiser, M., & Bode, H. B. (2020). Phototemtide A, a Cyclic Lipopeptide Heterologously Expressed from Photorhabdus temperata Meg1, Shows Selective Antiprotozoal Activity. CHEMBIOCHEM, 21(9), 1288-1292. doi:10.1002/cbic.201900665.

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Datensatz-Permalink: https://hdl.handle.net/21.11116/0000-000A-059C-1 Versions-Permalink: https://hdl.handle.net/21.11116/0000-000A-059D-0
Genre: Zeitschriftenartikel

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Zhao, Lei1, Autor           
Vo, Tien Duy2, Autor
Kaiser, Marcel2, Autor
Bode, Helge B.3, 4, Autor           
Affiliations:
1Chemical Genomics Center of the MPS, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753292              
2external, ou_persistent22              
3Natural Product Function and Engineering, Department of Natural Products in Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Max Planck Society, ou_3266308              
4Goethe-Universität Frankfurt am Main, External Organizations, ou_421891              

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 Zusammenfassung: A new cyclic lipopeptide, phototemtide A (1), was isolated from Escherichia coli expressing the biosynthetic gene cluster pttABC from Photorhabdus temperata Meg1. The structure of 1 was elucidated by HR-ESI-MS and NMR experiments. The absolute configurations of amino acids and 3-hydroxyoctanoic acid in 1 were determined by using the advanced Marfey's method and comparison after total synthesis of 1, respectively. Additionally, three new minor derivatives, phototemtides B-D (2-4), were identified by detailed HPLC-MS analysis. Phototemtide A (1) showed weak antiprotozoal activity against Plasmodium falciparum, with an IC50 value of 9.8 mu m. The biosynthesis of phototemtides A-D (1-4) was also proposed.

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 Datum: 2020
 Publikationsstatus: Erschienen
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 Art der Begutachtung: -
 Identifikatoren: ISI: 000510778400001
DOI: 10.1002/cbic.201900665
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Titel: CHEMBIOCHEM
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 21 (9) Artikelnummer: - Start- / Endseite: 1288 - 1292 Identifikator: ISSN: 1439-4227