(+/-)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from 
the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp.

Shi, Yan-Ni; Pusch, Stefan; Shi, Yi-Ming; Richter, Christian; Macia-Vicente, Jose G.; Schwalbe, Harald; Kaiser, Marcel; Opatz, Till; Bode, Helge B.

doi:10.1021/acs.joc.9b01229

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(+/-)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp.

Shi, Y.-N., Pusch, S., Shi, Y.-M., Richter, C., Macia-Vicente, J. G., Schwalbe, H., et al. (2019). (+/-)-Alternarlactones A and B, Two Antiparasitic Alternariol-like Dimers from the Fungus Alternaria alternata P1210 Isolated from the Halophyte Salicornia sp. JOURNAL OF ORGANIC CHEMISTRY, 84(17), 11203-11209. doi:10.1021/acs.joc.9b01229.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-0560-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-0561-3

Genre: Journal Article

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Creators:
Shi, Yan-Ni¹, Author
Pusch, Stefan², Author
Shi, Yi-Ming, Author
Richter, Christian², Author
Macia-Vicente, Jose G.², Author
Schwalbe, Harald², Author
Kaiser, Marcel², Author
Opatz, Till², Author
Bode, Helge B.¹, Author

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1Goethe-Universität Frankfurt am Main, External Organizations, ou_421891
2external, ou_persistent22

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Abstract: Two new dimeric compounds of the alternariol class, (+/-)-alternarlactones A (1) and B (2), were isolated along with 11 known compounds from the fungus Alternaria alternata P1210. Their structures were elucidated with the assistance of long-range HSQMBC to address inadequate cross-peaks in HMBC that result from the highly dense quaternary carbons, as well as theoretical calculations. All isolated altenuisol derivatives were screened for their antiparasitic activities, which provide a preliminary structure-activity relationship of this class of compounds against neglected tropical diseases.

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Dates: Date issued: 2019

Publication Status: Issued

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Identifiers: ISI: 000485089200064
DOI: 10.1021/acs.joc.9b01229

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Title: JOURNAL OF ORGANIC CHEMISTRY

Source Genre: Journal

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Pages: - Volume / Issue: 84 (17) Sequence Number: - Start / End Page: 11203 - 11209 Identifier: ISSN: 0022-3263