Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

Schimming, Olivia; Challinor, Victoria L.; Tobias, Nicholas J.; Adihou, Helene; Gruen, Peter; Poeschel, Laura; Richter, Christian; Schwalbe, Harald; Bode, Helge B.

doi:10.1002/anie.201504877

Local TagsRelease HistoryDetailsSummary

Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

Schimming, O., Challinor, V. L., Tobias, N. J., Adihou, H., Gruen, P., Poeschel, L., et al. (2015). Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(43), 12702-12705. doi:10.1002/anie.201504877.

Item is Released

show all hide all

Basic

show hide

Item Permalink: https://hdl.handle.net/21.11116/0000-000A-0532-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-0533-7

Genre: Journal Article

Files

show Files

Locators

show

Creators

show

hide

Creators:
Schimming, Olivia¹, Author
Challinor, Victoria L.¹, Author
Tobias, Nicholas J.¹, Author
Adihou, Helene¹, Author
Gruen, Peter¹, Author
Poeschel, Laura¹, Author
Richter, Christian¹, Author
Schwalbe, Harald¹, Author
Bode, Helge B.², Author

Affiliations:
1external, ou_persistent22
2Goethe-Universität Frankfurt am Main, External Organizations, ou_421891

Content

show

hide

Free keywords: -

Abstract: Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.

Details

show

hide

Language(s):

Dates: Date issued: 2015

Publication Status: Issued

Pages: -

Publishing info: -

Table of Contents: -

Rev. Type: -

Identifiers: ISI: 000363422700034
DOI: 10.1002/anie.201504877

Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show

hide

Title: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Source Genre: Journal

Creator(s):

Affiliations:

Publ. Info: -

Pages: - Volume / Issue: 54 (43) Sequence Number: - Start / End Page: 12702 - 12705 Identifier: ISSN: 1433-7851