A novel and widespread class of ketosynthase is responsible for the 
head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis

Kresovic, Darko; Schempp, Florence; Cheikh-Ali, Zakaria; Bode, Helge B.

doi:10.3762/bjoc.11.152

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A novel and widespread class of ketosynthase is responsible for the head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis

Kresovic, D., Schempp, F., Cheikh-Ali, Z., & Bode, H. B. (2015). A novel and widespread class of ketosynthase is responsible for the head-to-head condensation of two acyl moieties in bacterial pyrone biosynthesis. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 11, 1412-1417. doi:10.3762/bjoc.11.152.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-04FE-4 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-04FF-3

Genre: Journal Article

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Kresovic, Darko¹, Author
Schempp, Florence¹, Author
Cheikh-Ali, Zakaria¹, Author
Bode, Helge B.², Author

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1external, ou_persistent22
2Goethe-Universität Frankfurt am Main, External Organizations, ou_421891

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Abstract: The biosynthesis of photopyrones, novel quorum sensing signals in Photorhabdus, has been studied by heterologous expression of the photopyrone synthase PpyS catalyzing the head-to-head condensation of two acyl moieties. The biochemical mechanism of pyrone formation has been investigated by amino acid exchange and bioinformatic analysis. Additionally, the evolutionary origin of PpyS has been studied by phylogenetic analyses also revealing homologous enzymes in Pseudomonas sp. GM30 responsible for the biosynthesis of pseudopyronines including a novel derivative. Moreover this novel class of ketosynthases is only distantly related to other pyrone-forming enzymes identified in the biosynthesis of the potent antibiotics myxopyronin and corallopyronin.

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Dates: Date issued: 2015

Publication Status: Issued

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Identifiers: ISI: 000359455500001
DOI: 10.3762/bjoc.11.152

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Title: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Source Genre: Journal

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Pages: - Volume / Issue: 11 Sequence Number: - Start / End Page: 1412 - 1417 Identifier: ISSN: 1860-5397