Simple "On-Demand" Production of Bioactive Natural Products

Bode, Edna; Brachmann, Alexander O.; Kegler, Carsten; Simsek, Rukayye; Dauth, Christina; Zhou, Qiuqin; Kaiser, Marcel; Klemmt, Petra; Bode, Helge B.

doi:10.1002/cbic.201500094

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Simple "On-Demand" Production of Bioactive Natural Products

Bode, E., Brachmann, A. O., Kegler, C., Simsek, R., Dauth, C., Zhou, Q., et al. (2015). Simple "On-Demand" Production of Bioactive Natural Products. CHEMBIOCHEM, 16(7), 1115-1119. doi:10.1002/cbic.201500094.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000A-04FA-8 Version Permalink: https://hdl.handle.net/21.11116/0000-000A-04FB-7

Genre: Journal Article

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Creators:
Bode, Edna¹, Author
Brachmann, Alexander O.², Author
Kegler, Carsten³, Author
Simsek, Rukayye², Author
Dauth, Christina², Author
Zhou, Qiuqin², Author
Kaiser, Marcel², Author
Klemmt, Petra², Author
Bode, Helge B.¹, Author

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1Goethe-Universität Frankfurt am Main, External Organizations, ou_421891
2external, ou_persistent22
3External Organizations, ou_persistent22

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Abstract: Exchange of the native promoter to the arabinose-inducible promoter P-BAD was established in entomopathogenic bacteria to silence and/or activate gene clusters involved in natural product biosynthesis. This allowed the on-demand production of GameXPeptides, xenoamicins, and the blue pigment indigoidine. The gene clusters for the novel mevalagmapeptides and the highly toxic xenorhabdins were identified by this approach.

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Dates: Date issued: 2015

Publication Status: Issued

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Identifiers: ISI: 000353502300015
DOI: 10.1002/cbic.201500094

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Title: CHEMBIOCHEM

Source Genre: Journal

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Pages: - Volume / Issue: 16 (7) Sequence Number: - Start / End Page: 1115 - 1119 Identifier: ISSN: 1439-4227