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  Dialkylresorcinols as bacterial signaling molecules

Brameyer, S., Kresovic, D., Bode, H. B., & Heermann, R. (2015). Dialkylresorcinols as bacterial signaling molecules. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(2), 572-577. doi:10.1073/pnas.1417685112.

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Brameyer, Sophie, Author           
Kresovic, Darko1, Author
Bode, Helge B.2, Author           
Heermann, Ralf1, Author
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1external, ou_persistent22              
2Goethe-Universität Frankfurt am Main, External Organizations, ou_421891              

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 Abstract: It is well recognized that bacteria communicate via small diffusible molecules, a process termed quorum sensing. The best understood quorum sensing systems are those that use acylated homoserine lactones (AHLs) for communication. The prototype of those systems consists of a LuxI-like AHL synthase and a cognate LuxR receptor that detects the signal. However, many proteobacteria possess LuxR receptors, yet lack any LuxI-type synthase, and thus these receptors are referred to as LuxR orphans or solos. In addition to the well-known AHLs, little is known about the signaling molecules that are sensed by LuxR solos. Here, we describe a novel cell-cell communication system in the insect and human pathogen Photorhabdus asymbiotica. We identified the LuxR homolog PauR to sense dialkyl-resorcinols (DARs) and cyclohexanediones (CHDs) instead of AHLs as signals. The DarABC synthesis pathway produces the molecules, and the entire system emerged as important for virulence. Moreover, we have analyzed more than 90 different Photorhabdus strains by HPLC/MS and showed that these DARs and CHDs are specific to the human pathogen P. asymbiotica. On the basis of genomic evidence, 116 other bacterial species are putative DAR producers, among them many human pathogens. Therefore, we discuss the possibility of DARs as novel and widespread bacterial signaling molecules and show that bacterial cell-cell communication goes far beyond AHL signaling in nature.

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 Dates: 2015
 Publication Status: Issued
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 Identifiers: ISI: 000347732300072
DOI: 10.1073/pnas.1417685112
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Title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Source Genre: Journal
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Pages: - Volume / Issue: 112 (2) Sequence Number: - Start / End Page: 572 - 577 Identifier: ISSN: 0027-8424