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  Determination of the Absolute Configuration of Peptide Natural Products by Using Stable Isotope Labeling and Mass Spectrometry

Bode, H. B., Reimer, D., Fuchs, S. W., Kirchner, F., Dauth, C., Kegler, C., et al. (2012). Determination of the Absolute Configuration of Peptide Natural Products by Using Stable Isotope Labeling and Mass Spectrometry. CHEMISTRY-A EUROPEAN JOURNAL, 18(8), 2342-2348. doi:10.1002/chem.201103479.

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 Creators:
Bode, Helge B.1, Author           
Reimer, Daniela2, Author
Fuchs, Sebastian W.2, Author
Kirchner, Ferdinand2, Author
Dauth, Christina2, Author
Kegler, Carsten3, Author           
Lorenzen, Wolfram2, Author
Brachmann, Alexander O.2, Author
Gruen, Peter2, Author
Affiliations:
1Goethe-Universität Frankfurt am Main, External Organizations, ou_421891              
2external, ou_persistent22              
3External Organizations, ou_persistent22              

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 Abstract: Structure elucidation of natural products including the absolute configuration is a complex task that involves different analytical methods like mass spectrometry, NMR spectroscopy, and chemical derivation, which are usually performed after the isolation of the compound of interest. Here, a combination of stable isotope labeling of Photorhabdus and Xenorhabdus strains and their transaminase mutants followed by detailed MS analysis enabled the structure elucidation of novel cyclopeptides named GameXPeptides including their absolute configuration in crude extracts without their actual isolation.

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 Dates: 2012
 Publication Status: Issued
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 Identifiers: ISI: 000300500200024
DOI: 10.1002/chem.201103479
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Title: CHEMISTRY-A EUROPEAN JOURNAL
Source Genre: Journal
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Pages: - Volume / Issue: 18 (8) Sequence Number: - Start / End Page: 2342 - 2348 Identifier: ISSN: 0947-6539