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  In vivo quantification of the bound pool T1 in human white matter using the binary spin–bath model of progressive magnetization transfer saturation

Helms, G., & Hagberg, G. (2009). In vivo quantification of the bound pool T1 in human white matter using the binary spin–bath model of progressive magnetization transfer saturation. Physics in Medicine and Biology, 54(3), N529-N540. doi:10.1088/0031-9155/54/23/N01.

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Helms, G, Author
Hagberg, GE1, Author              
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1External Organizations, ou_persistent22              

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 Abstract: The relative size and relaxation of the invisible pool of bound spins (T1b) underlying magnetization transfer (MT) was quantified in eight subjects in vivo at 1.5 T from progressive saturation experiments using repetitive MT pulses. The evolution of the binary spin–bath was sampled by increasing the repetition period from 8 to 200 ms. Single-shot echo-planar images at TE = 50 ms were evaluated in the central white matter. Three models were fitted: the general solution, and with constraints of equal relaxation and T1b = 1 s for the invisible pool. The general solution of unconstrained T1b provided a significantly better fit, indicating fast-to-intermediate exchange. The bound pool fraction was 17 ± 4%, the relaxation times T1f = 1.6 ± 0.2 s for free water and T1b = 171 ± 22 ms for the bound pool. The constrained models did not differ from each other, since here T1b was similar to the observed T1 of 1.1 ± 0.1 s. They underestimate the bound pool fraction and its relaxation. Thus, the standard assumption of continuous-wave MT models may underestimate the relaxation via the bound pool by more than a factor of five.

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 Dates: 2009-12
 Publication Status: Published in print
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 Identifiers: DOI: 10.1088/0031-9155/54/23/N01
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Title: Physics in Medicine and Biology
  Other : Phys. Med. Biol.
Source Genre: Journal
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Publ. Info: London? : IOP Pub.
Pages: - Volume / Issue: 54 (3) Sequence Number: - Start / End Page: N529 - N540 Identifier: ISSN: 0031-9155
CoNE: https://pure.mpg.de/cone/journals/resource/954925433410