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  Voxel-based analysis of R2* maps in the healthy human brain

Perán, P., Hagberg, G., Luccichenti, G., Cherubini, A., Brainovich, V., Celsis, P., et al. (2007). Voxel-based analysis of R2* maps in the healthy human brain. Journal of Magnetic Resonance Imaging, 26(6), 1413-1420. doi:10.1002/jmri.21204.

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Perán, P, Author
Hagberg, G1, Author              
Luccichenti, G, Author
Cherubini, A, Author
Brainovich, V, Author
Celsis, P, Author
Caltagirone, C, Author
Sabatini, U, Author
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1External Organizations, ou_persistent22              

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 Abstract: Purpose To develop a voxel-based analysis of an R2* map of healthy human brain that is automatic, reproducible, and realizable in a single examination on a 3T MR imager. Such a tool could be useful to measure iron accumulation in neurodegenerative diseases. Materials and Methods In all, 18 healthy subjects underwent MR imaging at a field strength of 3T: 1) six consecutive T2*-weighted gradient-echo volumes were acquired using a segmented echo-planar imaging sequence and 2) a conventional dual-echo turbo spin echo sequence was also applied to acquire T2-weighted images. Images were realigned and spatial correction was performed using a template brain dataset with SPM2. For each subject we performed a voxel-by-voxel nonlinear least-squares fitting of the data acquired at the six echo times to obtain a monoexponential signal decay curve. The reproducibility and sensitivity to age variation were assessed by voxel-based analysis. Results The reproducibility tests in whole brain analysis showed little R2* variation. Furthermore, the statistical analysis, performed on each brain voxel, revealed a significant positive correlation between age and MR values located in regions where a slow and constant age-related iron deposition is known. Conclusion Our method, combining data acquisition and data processing, demonstrates the feasibility of voxel-based analysis on an R2* map and affords a high degree of sensitivity and good reproducibility while maintaining high spatial resolution.

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 Dates: 2007-12
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/jmri.21204
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Title: Journal of Magnetic Resonance Imaging
Source Genre: Journal
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Publ. Info: Chicago, IL : Society for Magnetic Resonance Imaging
Pages: - Volume / Issue: 26 (6) Sequence Number: - Start / End Page: 1413 - 1420 Identifier: ISSN: 1053-1807
CoNE: https://pure.mpg.de/cone/journals/resource/954925594512