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  Prevalence and correlates of current suicidal ideation in women with premenstrual dysphoric disorder

Wikman, A., Sacher, J., Bixo, M., Hirschberg, A. L., Kopp Kallner, H., Epperson, C. N., et al. (2022). Prevalence and correlates of current suicidal ideation in women with premenstrual dysphoric disorder. BMC Women's Health, 22(1): 35. doi:10.1186/s12905-022-01612-5.

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 Creators:
Wikman, Anna1, Author
Sacher, Julia2, Author           
Bixo, Marie3, Author
Hirschberg, Angelica L.4, 5, Author
Kopp Kallner, Helena6, 7, Author
Epperson, C. Neill8, Author
Comasco, Erika9, Author
Sundström Poromaa, Inger1, Author
Affiliations:
1Department of Women’s and Children’s Health, Uppsala University, Sweden, ou_persistent22              
2Minerva Research Group EGG (Emotion & neuroimaGinG) Lab, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3230775              
3Department of Clinical Sciences, Umeå University, Sweden, ou_persistent22              
4Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
5Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden, ou_persistent22              
6Department of Clinical Sciences, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
7Department of Obstetrics and Gynecology, Karolinska Institute, Stockholm, Sweden, ou_persistent22              
8Department of Psychiatry, University of Colorado School of Medicine, Aurora, CO, USA, ou_persistent22              
9Department of Neuroscience, Uppsala University, Sweden, ou_persistent22              

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Free keywords: MADRS-S; Premenstrual dysphoric disorder (PMDD); Prevalence; Suicidal ideation; Women’s health
 Abstract: Background: Although previous studies report an association between Premenstrual Dysphoric Disorder (PMDD) and suicidal ideation, most studies have only established a provisional and retrospective diagnosis of PMDD fundamentally invalidating the diagnosis. Therefore, the aim of this study was to describe the prevalence and to explore correlates of current suicidal ideation in the late luteal phase in women with prospectively assessed and confirmed PMDD. Methods: Participants were 110 women who attended the pre-randomization baseline visit of two randomized placebo-controlled clinical trials between January 15, 2017 and October 19, 2019. PMDD was diagnosed prospectively in line with DSM-5 criteria. Current suicidal ideation was measured by the MADRS-S in the late luteal phase. Descriptive statistics were presented and logistic regression analyses were carried out to explore the association between psychosocial and health characteristics and current suicidal ideation, presenting unadjusted odds ratios (OR) and 95% confidence intervals (CI). Results: Current suicidal ideation was reported by nearly 40% of women with confirmed PMDD (n = 43, 39.1%). Previous psychological treatment for PMDD and higher depressive symptoms in the late luteal phase were positively associated with current suicidal ideation (OR 5.63, 95% CI 1.07-29.49, and OR 1.17, 95% CI 1.10-1.25, respectively), whereas higher ratings of self-rated health were associated with lower odds ratios for current suicidal ideation (OR 0.98, 95% CI 0.96-0.99). Conclusions: A substantial proportion of women with confirmed PMDD report current suicidal ideation in the late luteal phase. Results point to a need for better awareness and screening of suicidal ideation in women with PMDD.

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Language(s): eng - English
 Dates: 2021-05-252022-01-292022-02-11
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1186/s12905-022-01612-5
PMID: 35148753
PMC: PMC8832802
 Degree: -

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Project name : -
Grant ID : 2015-00495, 2016-01439 and 2020-01801
Funding program : -
Funding organization : Swedish Research Council
Project name : -
Grant ID : SLS-573171, SLS-597211, SLS-789101
Funding program : -
Funding organization : Swedish Society of Medicine

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Title: BMC Women's Health
Source Genre: Journal
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Publ. Info: London : BioMed Central
Pages: - Volume / Issue: 22 (1) Sequence Number: 35 Start / End Page: - Identifier: ISSN: 1472-6874
CoNE: https://pure.mpg.de/cone/journals/resource/1472-6874