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  Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact

Fan, Q., Eichner, C., Afzali, M., Mueller, L., Tax, C. M., Davids, M., et al. (2022). Mapping the human connectome using diffusion MRI at 300 mT/m gradient strength: Methodological advances and scientific impact. NeuroImage, 118958. doi:10.1016/j.neuroimage.2022.118958.

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 Creators:
Fan, Qiuyun, Author
Eichner, Cornelius1, Author              
Afzali, Maryam, Author
Mueller, Lars, Author
Tax, Chantal M.W., Author
Davids, Mathias, Author
Mahmutovic, Mirsad, Author
Keil, Boris, Author
Bilgic, Berkin, Author
Setsompop, Kawin, Author
Lee, Hong-Hsi, Author
Tian, Qiyuan, Author
Maffei, Chiara, Author
Ramos-Llordén, Gabriel, Author
Nummenmaa, Aapo, Author
Witzel, Thomas, Author
Yendiki, Anastasia, Author
Song, Yi-Qiao, Author
Huang, Chu-Chung, Author
Lin, Ching-Po, Author
Weiskopf, Nikolaus2, Author              Anwander, Alfred1, Author              Jones, Derek K., AuthorRosen, Bruce R., AuthorWald, Lawrence L., AuthorHuang, Susie Y., Author more..
Affiliations:
1Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Diffusion MRI; Human Connectome Project (HCP); Axon diameter; Brain; White matter; High b-value; Human connectome scanner; Peripheral nerve stimulation; Radio frequency coil; Sequence; Preprocessing; Fiber tracking data sharing tissue microstructure clinical applications
 Abstract: Tremendous efforts have been made in the last decade to advance cutting-edge MRI technology in pursuit of mapping structural connectivity in the living human brain with unprecedented sensitivity and speed. The first Connectom 3T MRI scanner equipped with a 300 mT/m whole-body gradient system was installed at the Massachusetts General Hospital in 2011 and was specifically constructed as part of the Human Connectome Project. Since that time, numerous technological advances have been made to enable the broader use of the Connectom high gradient system for diffusion tractography and tissue microstructure studies and leverage its unique advantages and sensitivity to resolving macroscopic and microscopic structural information in neural tissue for clinical and neuroscientific studies. The goal of this review article is to summarize the technical developments that have emerged in the last decade to support and promote large-scale and scientific studies of the human brain using the Connectom scanner. We provide a brief historical perspective on the development of Connectom gradient technology and the efforts that led to the installation of three other Connectom 3T MRI scanners worldwide – one in the United Kingdom in Cardiff, Wales, another in Continental Europe in Leipzig, Germany, and the latest in Asia in Shanghai, China. We summarize the key developments in gradient hardware and image acquisition technology that have formed the backbone of Connectom-related research efforts, including the rich array of high-sensitivity receiver coils, pulse sequences, image artifact correction strategies and data preprocessing methods needed to optimize the quality of high-gradient strength dMRI data for subsequent analyses. Finally, we review the scientific impact of the Connectom MRI scanner, including advances in diffusion tractography, tissue microstructural imaging, ex vivo validation, and clinical investigations that have been enabled by Connectom technology. We conclude with brief insights into the unique value of strong gradients for dMRI and where the field is headed in the coming years.

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Language(s): eng - English
 Dates: 2022-01-272021-08-082022-01-312022-02-23
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2022.118958
 Degree: -

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Project name : -
Grant ID : U01MH093765, U01-EB026996, P41-EB030006, K23-NS096056, R01-EB028797, U01-EB025162, R03-EB031175, R01-EB020613, R01-MH116173, R01-EB019437, R01-EB016695, and R01-NS118187
Funding program : -
Funding organization : National Institute of Health
Project name : -
Grant ID : 82071994
Funding program : -
Funding organization : National Natural Science Foundation of China
Project name : -
Grant ID : 2018SHZDZX01
Funding program : -
Funding organization : Shanghai Municipal Science and Technology Major Project
Project name : -
Grant ID : 219536/Z/19/Z
Funding program : -
Funding organization : Wellcome Trust
Project name : -
Grant ID : FP7/2007-2013, 616905
Funding program : -
Funding organization : European Research Council
Project name : Horizon 2020
Grant ID : 681094
Funding program : -
Funding organization : European Union
Project name : -
Grant ID : 01EW1711A & B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung (BMBF)

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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: - Sequence Number: 118958 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166