English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease

Cerasa, A., Hagberg, G., Peppe, A., Bianciardi, M., Gioia, M., Costa, A., et al. (2006). Functional changes in the activity of cerebellum and frontostriatal regions during externally and internally timed movement in Parkinson's disease. Brain Research Bulletin, 71(1-3), 259-269. doi:10.1016/j.brainresbull.2006.09.014.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Cerasa, A, Author
Hagberg, GE1, Author           
Peppe, A, Author
Bianciardi, M, Author
Gioia, MC, Author
Costa, A, Author
Castriota-Scanderbeg, A, Author
Caltagirone, C, Author
Sabatini, U, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: We used fMRI to investigate the neurofunctional basis of externally and internally timed movements in Parkinson's disease (PD) patients. Ten PD patients whose medication had been withheld for at least 18 h and 11 age- and sex-matched healthy controls were scanned while performing continuation paradigm with a visual metronome. Compared with the controls, PD patients displayed an intact capability to store and reproduce movement frequencies but with a significantly increased movement latencies. No differences in BOLD response were found in both groups when comparing the continuation with the preceding synchronization phase and viceversa, except for activity in visually related regions. Relative to healthy controls during the synchronization phase, PD patients exhibited an overall signal increase in the cerebellum and frontostriatal circuit (putamen, SMA and thalamus) activity together with specific brain areas (right inferior frontal gyrus and insula cortex) that are also implicated in primary timekeeper processes. By contrast, in the continuation phase the only neural network involved to a greater extent by the PD group was the cerebello-thalamic pathway. The lack of neurofunctional differences between the two timing phases suggests that rhythmic externally and internally guided movements engage similar neural networks in PD and matched healthy controls. Moreover, between-group comparison indicates that PD patients OFF medication may compensate for their basal ganglia–cortical loop's dysfunction using different motor pathways involving cerebellum and basal ganglia relays during the two phases of rhythmic movement.

Details

show
hide
Language(s):
 Dates: 2006-12
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Brain Research Bulletin
  Other : Brain Res. Bull.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Phoenix, N.Y. : Elsevier
Pages: - Volume / Issue: 71 (1-3) Sequence Number: - Start / End Page: 259 - 269 Identifier: ISSN: 0361-9230
CoNE: https://pure.mpg.de/cone/journals/resource/954925522699