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  Sculpting with stem cells: how models of embryo development take shape.

Veenvliet, J. V., Lenne, P.-F., Turner, D. A., Nachman, I., & Trivedi, V. (2021). Sculpting with stem cells: how models of embryo development take shape. Development (Cambridge, England), 148(24): dev192914. doi:10.1242/dev.192914.

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Veenvliet, Jesse V1, Autor           
Lenne, Pierre-François, Autor
Turner, David A, Autor
Nachman, Iftach, Autor
Trivedi, Vikas, Autor
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Zusammenfassung: During embryogenesis, organisms acquire their shape given boundary conditions that impose geometrical, mechanical and biochemical constraints. A detailed integrative understanding how these morphogenetic information modules pattern and shape the mammalian embryo is still lacking, mostly owing to the inaccessibility of the embryo in vivo for direct observation and manipulation. These impediments are circumvented by the developmental engineering of embryo-like structures (stembryos) from pluripotent stem cells that are easy to access, track, manipulate and scale. Here, we explain how unlocking distinct levels of embryo-like architecture through controlled modulations of the cellular environment enables the identification of minimal sets of mechanical and biochemical inputs necessary to pattern and shape the mammalian embryo. We detail how this can be complemented with precise measurements and manipulations of tissue biochemistry, mechanics and geometry across spatial and temporal scales to provide insights into the mechanochemical feedback loops governing embryo morphogenesis. Finally, we discuss how, even in the absence of active manipulations, stembryos display intrinsic phenotypic variability that can be leveraged to define the constraints that ensure reproducible morphogenesis in vivo.

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 Datum: 2021-12-15
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.1242/dev.192914
Anderer: cbg-8285
PMID: 34908102
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Titel: Development (Cambridge, England)
  Andere : Development
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 148 (24) Artikelnummer: dev192914 Start- / Endseite: - Identifikator: -