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  Fast detection of diffuse axonal damage in severe traumatic brain injury: comparison of gradient-recalled echo and turbo proton echo-planar spectroscopic imaging MRI sequences

Giugni, E., Sabatini, U., Hagberg, G., Formisano, R., & Castriota-Scanderbeg, A. (2005). Fast detection of diffuse axonal damage in severe traumatic brain injury: comparison of gradient-recalled echo and turbo proton echo-planar spectroscopic imaging MRI sequences. American Journal of Neuroradiology, 26(5), 1140-1148.

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Giugni, E, Author
Sabatini, U, Author
Hagberg, GE1, Author              
Formisano, R, Author
Castriota-Scanderbeg, A, Author
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1External Organizations, ou_persistent22              

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 Abstract: Background and purpose: Diffuse axonal injury (DAI) is a common type of primary neuronal injury in patients with severe traumatic brain injury (TBI), and is frequently accompanied by tissue tear hemorrhage. T2-weighted gradient-recalled echo (GRE) sequences are more sensitive than T2-weighted spin-echo images for detection of hemorrhage. The purpose of this study is to compare turbo Proton Echo Planar Spectroscopic Imaging (t-PEPSI), an extremely fast sequence, with GRE sequence in the detection of DAI. Methods: Twenty-one patients (mean age 26.8 years) with severe TBI occurred at least 3 months earlier, underwent a brain MR Imaging study on a 1.5-T scanner. A qualitative evaluation of the t-PEPSI sequences was performed by identifying the optimal echo time and in-plane resolution. The number and size of DAI lesions, as well as the signal intensity contrast ratio (SI CR), were computed for each set of GRE and t-PEPSI images, and divided according to their anatomic location as lobar and/or deep brain. Results: There was no significant difference between GRE and t-PEPSI sequences in the detection of the total number of DAI lesions (291 vs. 230, respectively). GRE sequence delineated a higher number of DAI in the temporal lobe compared to the t-PEPSI sequence (74 vs. 37, P < .004), while no differences were found for the other regions. The SI CR was significantly lower with the t-PEPSI than the GRE sequence (P < .00001). Conclusion: Owing to its very short scan time and high sensitivity to the hemorrhage foci, the t-PEPSI sequence may be used as an alternative to the GRE to assess brain DAI in severe TBI patients, especially if uncooperative and medically unstable.

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 Dates: 2005-05
 Publication Status: Published in print
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 Identifiers: PMID: 15891173
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Title: American Journal of Neuroradiology
Source Genre: Journal
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Publ. Info: Baltimore : Williams & Wilkins Co.
Pages: - Volume / Issue: 26 (5) Sequence Number: - Start / End Page: 1140 - 1148 Identifier: ISSN: 0195-6108
CoNE: https://pure.mpg.de/cone/journals/resource/954925490872