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  Perception is associated with the brain's metabolic response to sensory stimulation

DiNuzzo, M., Mangia, S., Moraschi, M., Mascali, D., Hagberg, G., & Giove, F. (2022). Perception is associated with the brain's metabolic response to sensory stimulation. eLife, 11: e71016. doi:10.7554/eLife.71016.

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https://elifesciences.org/articles/71016 (Publisher version)
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 Creators:
DiNuzzo, M, Author
Mangia, S, Author
Moraschi, M, Author
Mascali, D, Author
Hagberg, GE1, 2, Author              
Giove, F, Author
Affiliations:
1Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, Spemannstrasse 38, 72076 Tübingen, DE, ou_1497794              

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 Abstract: Processing of incoming sensory stimulation triggers an increase of cerebral perfusion and blood oxygenation (neurovascular response) as well as an alteration of the metabolic neurochemical profile (neurometabolic response). Here we show in human primary visual cortex (V1) that perceived and unperceived isoluminant chromatic flickering stimuli designed to have similar neurovascular responses as measured by blood oxygenation level dependent functional MRI (BOLD-fMRI) have markedly different neurometabolic responses as measured by functional MRS. In particular, a significant regional buildup of lactate, an index of aerobic glycolysis, and glutamate, an index of malate-aspartate shuttle, occurred in V1 only when the flickering was perceived, without any relation with behavioral or physiological variables. Whereas the BOLD-fMRI signal in V1, a proxy for input to V1, was insensitive to flickering perception by design, the BOLD-fMRI signal in secondary visual areas was larger during perceived than unperceived flickering, indicating increased output from V1. These results demonstrate that the upregulation of energy metabolism induced by visual stimulation depends on the type of information processing taking place in V1, and that 1H-fMRS provides unique information about local input/output balance that is not measured by BOLD fMRI.

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 Dates: 2022-02
 Publication Status: Published online
 Pages: -
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 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.71016
eDoc: e71016
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Title: eLife
Source Genre: Journal
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Publ. Info: Cambridge : eLife Sciences Publications
Pages: 20 Volume / Issue: 11 Sequence Number: e71016 Start / End Page: - Identifier: ISSN: 2050-084X
CoNE: https://pure.mpg.de/cone/journals/resource/2050-084X