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  Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy

Harbauer, A. B., Hees, J. T., Wanderoy, S., Segura, I., Gibbs, W., Cheng, Y., et al. (2022). Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron, 110(9), 1516-1531.e9. doi:10.1016/j.neuron.2022.01.035.

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 Creators:
Harbauer, Angelika B.1, Author           
Hees, J. Tabitha1, Author           
Wanderoy, Simone1, Author           
Segura, Inmaculada1, Author           
Gibbs, Whitney, Author
Cheng, Yiming, Author
Ordonez, Martha, Author
Cai, Zerong, Author
Cartoni, Romain, Author
Ashrafi, Ghazaleh, Author
Wang, Chen, Author
Perocchi, Fabiana, Author
He, Zhigang, Author
Schwarz, Thomas L., Author
Affiliations:
1Max Planck Research Group: Neurometabolism / Harbauer, MPI of Neurobiology, Max Planck Society, ou_3232739              

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 Abstract: PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to be trafficked into neurites, local translation is required for this mitophagy pathway to be active far from the soma. The Pink1 transcript is associated and cotransported with neuronal mitochondria. In concert with translation, the mitochondrial outer membrane proteins synaptojanin 2 binding protein (SYNJ2BP) and synaptojanin 2 (SYNJ2) are required for tethering Pink1 mRNA to mitochondria via an RNA-binding domain in SYNJ2. This neuron-specific adaptation for the local translation of PINK1 provides distal mitochondria with a continuous supply of PINK1 for the activation of mitophagy.

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 Dates: 2022-05-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: Other: MEDLINE:35216662
DOI: 10.1016/j.neuron.2022.01.035
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 110 (9) Sequence Number: - Start / End Page: 1516 - 1531.e9 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565