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Abstract:
The mouse hematopoietic system has served as a paradigm for analysis of developmental fate decisions in
tissue homeostasis and regeneration. However, multiple immunophenotypic definitions of, and sometimes
divergent nomenclatures used to classify, murine multipotent progenitors (MPPs) have emerged in the field
over time. This has created significant confusion and inconsistency in the hematology field. To facilitate easier
comparison of murine MPP phenotypes between research laboratories, a working group of four International
Society for Experimental Hematology (ISEH) members with extensive experience studying the
functional activities associated with different MPP phenotypic definitions reviewed the current state of the
field with the goal of developing a position statement toward a simplified and unified immunophenotypic definition
of MPP populations. In November of 2020, this position statement was presented as a webinar to the
ISEH community for discussion and feedback. Hence, the Simplified MPP Identification Scheme presented
here is the result of curation of existing literature, consultation with leaders in the field, and crowdsourcing
from the wider experimental hematology community. Adoption of a unified definition and nomenclature,
while still leaving room for individual investigator customization, will benefit scientists at all levels trying to
compare these populations between experimental settings.
